Michael J. Cromie
Washington University in St. Louis
9 Papers
Michael J. Cromie is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Gene & Lipid A. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Michael J. Cromie include Howard Hughes Medical Institute.
Chat about Author
Papers
An RNA Sensor for Intracellular Mg2
TL;DR: The initiation of mgtA transcription responds to extracytoplasmic Mg(2+) and its elongation into the coding region to cytoplasts to provide a singular example in which the same ligand is sensed in different cellular compartments to regulate disparate steps in gene transcription.
330
Fe(III)-mediated cellular toxicity
TL;DR: It is reported that Fe( III) exhibits microbicidal activity towards strains of Salmonella enterica, Escherichia coli and Klebsiella pneumoniae defective in the Fe(III)‐responding PmrA/PmrB signal transduction system.
90
Promoter and Riboswitch Control of the Mg2+ Transporter MgtA from Salmonella enterica
TL;DR: The MgtA protein from Salmonella enterica serovar Typhimurium mediates Mg(2+) uptake from the periplasm into the cytoplasm and the PhoP/PhoQ two-component regulatory system governs mgtA transcription initiation at all investigated Mg (2+) concentrations.
A Mg2+-responding RNA that controls the expression of a Mg2+ transporter.
TL;DR: It is determined that expression of the PhoP-activated Mg2+ transporter MgtA is also controlled by its 5'-untranslated region (5'UTR), which makes the mgtA 5'utR the first example of a cation-responding riboswitch.
A bacterial mRNA leader that employs different mechanisms to sense disparate intracellular signals.
TL;DR: This work reports that the leader RNA of the Mg(2+) transporter gene mgtA of Salmonella enterica harbors an 18 codon proline-rich open reading frame-termed mgtL-that permits intracellular proline to regulatemgtA expression.