Michael J. Cork
University of Sheffield
255 Papers
2.4K Citations
Michael J. Cork is an academic researcher from University of Sheffield. The author has contributed to research in topics: Medicine & Atopic dermatitis. The author has an hindex of 52, co-authored 192 publications. Previous affiliations of Michael J. Cork include Boston Children's Hospital & Paul Sabatier University.
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Papers
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Eric L. Simpson,Thomas Bieber,Emma Guttman-Yassky,Lisa A. Beck,Andrew Blauvelt,Michael J. Cork,Jonathan I. Silverberg,Mette Deleuran,Yoko Kataoka,Jean-Philippe Lacour,Külli Kingo,Margitta Worm,Margitta Worm,Yves Poulin,Andreas Wollenberg,Yuhwen Soo,Neil M.H. Graham,Gianluca Pirozzi,Bolanle Akinlade,Heribert Staudinger,Vera Mastey,Laurent Eckert,Abhijit Gadkari,Neil Stahl,George D. Yancopoulos,Marius Ardeleanu +25 more
TL;DR: Dupilumab improved the signs and symptoms of atopic dermatitis, including pruritus, symptoms of anxiety and depression, and quality of life, as compared with placebo in two phase 3 trials of identical design.
Adverse Effects of Topical Glucocorticosteroids
TL;DR: An updated review of local and systemic adverse effects upon administration of topical corticosteroids, including the latest FDA report on the safety of such steroids in children, is provided.
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A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1
Amy Strange,Francesca Capon,Chris C. A. Spencer,Jo Knight,Michael E. Weale,Michael H. Allen,Anne Barton,Gavin Band,Céline Bellenguez,Judith G.M. Bergboer,Jenefer M. Blackwell,Elvira Bramon,Suzannah Bumpstead,Juan P. Casas,Michael J. Cork,Aiden Corvin,Panos Deloukas,Alexander T. Dilthey,Audrey Duncanson,Sarah Edkins,Xavier Estivill,Oliver FitzGerald,Colin Freeman,Emiliano Giardina,Emma Gray,Angelika Hofer,Ulrike Hüffmeier,Sarah E. Hunt,Alan D. Irvine,Janusz Jankowski,Brian Kirby,Cordelia Langford,Jesús Lascorz,Joyce Leman,Stephen Leslie,Lotus Mallbris,Hugh S. Markus,Christopher G. Mathew,W.H. Irwin McLean,Ross McManus,Rotraut Mössner,Loukas Moutsianas,Åsa Torinsson Naluai,Frank O. Nestle,Giuseppe Novelli,Alexandros Onoufriadis,Colin N. A. Palmer,Carlo Perricone,Matti Pirinen,Robert Plomin,Simon C. Potter,Ramon M. Pujol,Anna Rautanen,Eva Riveira-Muñoz,Anthony W. Ryan,Wolfgang Salmhofer,Lena Samuelsson,Stephen Sawcer,Joost Schalkwijk,Catherine H. Smith,Mona Ståhle,Zhan Su,Rachid Tazi-Ahnini,Heiko Traupe,Ananth C. Viswanathan,Ananth C. Viswanathan,Richard B. Warren,Wolfgang Weger,Katarina Wolk,Nicholas W. Wood,Jane Worthington,Helen S. Young,Patrick L.J.M. Zeeuwen,Adrian Hayday,A. David Burden,Christopher E.M. Griffiths,Juha Kere,André Reis,Gilean McVean,David M. Evans,Matthew A. Brown,Jonathan Barker,Leena Peltonen,Peter Donnelly,Peter Donnelly,Richard C. Trembath +85 more
TL;DR: These findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis and report compelling evidence for an interaction between the HLA-C and ERAP1 loci.
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Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Lam C. Tsoi,Sarah L. Spain,Sarah L. Spain,Jo Knight,Eva Ellinghaus,Eva Ellinghaus,Philip E. Stuart,Francesca Capon,Jun Ding,Yanming Li,Trilokraj Tejasvi,Johann E. Gudjonsson,Hyun Min Kang,Michael H. Allen,Ross McManus,Giuseppe Novelli,Lena Samuelsson,Joost Schalkwijk,Mona Ståhle,A. David Burden,Catherine H. Smith,Michael J. Cork,Xavier Estivill,Anne M. Bowcock,Gerald G. Krueger,Wolfgang Weger,Jane Worthington,Rachid Tazi-Ahnini,Frank O. Nestle,Adrian Hayday,Per Hoffmann,Juliane Winkelmann,Cisca Wijmenga,Cordelia Langford,Sarah Edkins,Robert Andrews,Hannah Blackburn,Amy Strange,Gavin Band,Richard D. Pearson,Damjan Vukcevic,Chris C. A. Spencer,Panos Deloukas,Ulrich Mrowietz,Stefan Schreiber,Stephan Weidinger,Sulev Kõks,Külli Kingo,Tõnu Esko,Andres Metspalu,Henry W. Lim,John J. Voorhees,Michael Weichenthal,H.-Erich Wichmann,Vinod Chandran,Cheryl F. Rosen,Proton Rahman,Dafna D. Gladman,Christopher E.M. Griffiths,André Reis,Juha Kere,Juha Kere,Rajan P. Nnair,Andre Franke,Jonathan Nn Barker,Ggoncalo R. Abecasis,James Tt Eelder,Richard Ttrembath,Richard Ttrembath,Kristina Callis Duffin,Cindy Helms,David E. Goldgar,Yun Li,Justin Paschall,Justin Paschall,Mary J. Malloy,Mary J. Malloy,Clive R. Pullinger,Clive R. Pullinger,John P. Kane,John P. Kane,Jennifer M. Gardner,Amy Perlmutter,Andrew Miner,Bing Jian Feng,Ravi Hiremagalore,Robert W. Ike,Enno Christophers,Tilo Henseler,Andreas Ruether,Steven J. Schrodi,Sampath Prahalad,Sampath Prahalad,Stephen L. Guthery,Stephen L. Guthery,Judith Fischer,Wilson Liao,Pui Kwok,Alan Menter,G. Mark Lathrop,Carol Wise,Ann B. Begovich,Alexandros Onoufriadis,Michael E. Weale,Angelika Hofer,Wolfgang Salmhofer,Peter Wolf,Kati Kainu,Ulpu Saarialho-Kere,Sari Suomela,Petra Badorf,Ulrike Hüffmeier,Werner Kurrat,Wolfgang Küster,Jesús Lascorz,Rotraut Mössner,Funda Schürmeier-Horst,Markward Ständer,Heiko Traupe,Judith G.M. Bergboer,Martin den Heijer,Martin den Heijer,Peter C.M. van de Kerkhof,Patrick L.J.M. Zeeuwen,L. Barnes,Linda E. Campbell,Caitriona Cusack,Ciara Coleman,Judith Conroy,Sean Ennis,Oliver FitzGerald,Phil Gallagher,Alan D. Irvine,Brian Kirby,Trevor Markham,W.H. Irwin McLean,Joe McPartlin,Sarah Rogers,Anthony W. Ryan,Agnieszka Zawirska,Emiliano Giardina,Tiziana Lepre,Carlo Perricone,Gemma Martin-Ezquerra,Ramon M. Pujol,Eva Riveira-Muñoz,Annica Inerot,Åsa Torinsson Naluai,Lotus Mallbris,Katarina Wolk,Joyce Leman,Anne Barton,Richard B. Warren,Helen S. Young,Isis Ricaño-Ponce,Gosia Trynka,Fawnda Pellett,Andrew Henschel,Marin Aurand,Bruce F. Bebo,Christian Gieger,Thomas Illig,Susanne Moebus,Karl-Heinz Jöckel,Raimund Erbel,Peter Donnelly,Peter Donnelly,Leena Peltonen,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Aiden Corvin,Nicholas Craddock,Audrey Duncanson,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Mark I. McCarthy,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Stephen J. Sawcer,Nilesh J. Samani,Ananth C. Viswanathan,Nicholas W. Wood,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Zhan Su,Sarah E. Hunt,Rhian Gwilliam,Suzannah Bumpstead,Serge Dronov,Matthew W. Gillman,Emma Gray,Naomi Hammond,Alagurevathi Jayakumar,O. T. McCann,Jennifer Liddle,M. Perez,Simon C. Potter,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,Rajan P. Neir,Jonathan Barker,Gonçalo R. Abecasis,James T. Elder,Richard C. Trembath +215 more
TL;DR: A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
Epidermal Barrier Dysfunction in Atopic Dermatitis
Michael J. Cork,Simon G. Danby,Yiannis Vasilopoulos,Jonathan Hadgraft,Majella E. Lane,Manar Moustafa,Manar Moustafa,Richard H. Guy,Alice Macgowan,Rachid Tazi-Ahnini,Simon J. Ward +10 more
TL;DR: The strong association between both genetic barrier defects and environmental insults to the barrier with AD suggests that epidermal barrier dysfunction is a primary event in the development of this disease.
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