Michael J. Cooke
Durham University
43 Papers
152 Citations
Michael J. Cooke is an academic researcher from Durham University. The author has contributed to research in topics: Transplantation & Progenitor cell. The author has an hindex of 22, co-authored 42 publications. Previous affiliations of Michael J. Cooke include University of Toronto & Newcastle University.
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Papers
Derivation of Human Embryonic Stem Cells from Developing and Arrested Embryos
Xin Zhang,Petra Stojkovic,Stefan Przyborski,Michael J. Cooke,Lyle Armstrong,Majlinda Lako,Miodrag Stojkovic +6 more
TL;DR: Analysis of arrested embryos demonstrated that these embryos express pluripotency marker genes such OCT4, NANOG, and REX1, which demonstrate that arrested embryos are additional valuable resources to surplus and donated developing embryos and should be used to study early human development or derive pluripotent hESC.
216
A Hyaluronan-Based Injectable Hydrogel Improves the Survival and Integration of Stem Cell Progeny following Transplantation
Brian G. Ballios,Michael J. Cooke,Laura Donaldson,Brenda L. K. Coles,Cindi M. Morshead,Derek van der Kooy,Molly S. Shoichet +6 more
TL;DR: The proposed injectable and bioresorbable hydrogel blend of hyaluronan and methylcellulose (HAMC) improves cell survival and integration of retinal stem cell-derived rods in the retina and improves cell transplantation efficacy in two CNS models, suggesting broad applicability.
208
Hydrogel delivery of erythropoietin to the brain for endogenous stem cell stimulation after stroke injury.
TL;DR: Erythropoietin delivered from HAMC at 4 and 11 days post-stroke resulted in attenuated inflammatory response, reduced stroke cavity size, increased number of both neurons in the peri-infarct region and migratory neuroblasts in the subventricular zone, and decreased apoptosis in both the subventionricular zone and the injured cortex.
164
Controlled epi-cortical delivery of epidermal growth factor for the stimulation of endogenous neural stem cell proliferation in stroke-injured brain
TL;DR: The epi-cortical delivery system is a minimally-invasive method for local delivery to the brain, providing a new paradigm for local delivered molecules directly to the head without tissue damage.
127
The effects of peptide modified gellan gum and olfactory ensheathing glia cells on neural stem/progenitor cell fate
Nuno A. Silva,Michael J. Cooke,Roger Y. Tam,Nuno Sousa,António J. Salgado,Rui L. Reis,Molly S. Shoichet +6 more
TL;DR: Results suggest that this co-culture strategy of NSPCs with OEG may have therapeutic benefit for SCI repair, and the importance of GRGDS for cell-GG interaction is demonstrated.
126