The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.

High throughput screening assay systems in microscale fluidic devices

This invention provides methods an apparatus for detecting and quantifying particulate matter suspended in a fluid. Specifically, the invention provides an integrated, affinity-binding based, analytical system comprising a platform for performing an affinity-binding based assay for specifically binding particulates including microbial cells, and a detection means for detecting the particulates specifically bound to a defined surface or chamber comprising the platform. Methods for using the analytical systems of the invention are also provided.

Affinity binding-based system for detecting particulates in a fluid

Methods and apparatus for screening large numbers of chemical compounds and performing a wide variety of fluorescent assays, including live cell assays. The methods utilize a laser linescan confocal microscope with high speed, high resolution and multi-wavelength capabilities and real time data-processing. Imaging may be done at video-rates and with use of ultraviolet illumination.

Method and apparatus for screening chemical compounds

The present invention provides for systems and methods that utilize automated and integratable workstations for identifying chemicals having useful activity. The present invention is also directed to chemical entities and information (e.g., chemical or biological activities of chemicals) generated or discovered by operation of workstations of the present invention. The present invention includes automated workstations that are programmably controlled to minimize processing times at each workstation and that can be integrated to minimize the processing time of the liquid samples from the start to finish of the process.

Systems and methods for rapidly identifying useful chemicals in liquid samples

A multi-channel system for classifying particles in a mixture of particles according to one or more characteristics including a common source of electromagnetic radiation for producing a beam of electromagnetic radiation and a beam splitter for producing multiple beams of electromagnetic radiation for directing multiple beams of electromagnetic radiation to each interrogation location associated with each flow channel of the multi-channel system.

Apparatus, methods and processes for sorting particles and for providing sex-sorted animal sperm

The apparatus and method of the present invention disclose a scanning imaging cytometer wherein an unprocessed biological fluid sample is reacted with a fluorescently-labeled binding agent. The reacted sample undergoes minimal processing before it is placed into a capillary tube. The sample is optically scanned and fluorescence excitation is recorded from a plurality of columnar regions of the capillary tube, each columnar region generally defined by the spot size of the excitation beam and the depth dimension of the capillary tube. A spatial filter of a sufficient pinhole diameter is selected to allow simultaneous volumetric detection of all fluorescent targets in each columnar region.

Apparatus and method for volumetric capillary cytometry

The apparatus and method of the present invention disclose a scanning optical system, including a laser (10) for generating an excitation beam of coherent light (80) and a lens (19) to direct the excitation beam of light (80) on a columnar region of a sample container (20), wherein a fluid sample is reacted with a fluorescently-labeled binding agent. The reacted sample undergoes minimal processing before it is placed into sample container (20). The sample is optically scanned, emitted fluorescence is collected by the lens (19) and directed as retrobeam (83) to a mirror (22) and through a collimating lens (23), and fluorescence excitation is recorded by a detector (31) from a plurality of columnar regions of the container (20), each columnar regino generally defined by the spot size (33) of the excitation beam (80) and the depth of field of detection. A spatial filter (24) of a sufficient pinhole diameter is selected to limit depth of field to allow simultaneous volumetric detection of fluorescent targets (45) in each columnar region.

Apparatus and method for optical detection in a limited depth of field

Apparatus and method for cytometry using a capillary of defined volume

Vorrichtung und Verfahren zur Zytometrie unter Verwendung einer Kapillarküvette mit definiertem Volumen

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Apparatus and method for volumetric capillary cytometry

Apparatus and method for optical detection in a limited depth of field

Apparatus and method for cytometry using a capillary of defined volume

Vorrichtung und Verfahren zur Zytometrie unter Verwendung einer Kapillarküvette mit definiertem Volumen