Michael H. Roh
University of Michigan
7 Papers
Michael H. Roh is an academic researcher from University of Michigan. The author has contributed to research in topics: PDZ domain & Tight junction. The author has an hindex of 7, co-authored 7 publications.
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Papers
Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.
TL;DR: The identification of a biochemical and functional link between these two complexes that is mediated by Par6 and PALS1 is highlighted, highlighting a previously unrecognized link between protein complexes that are essential for epithelial polarity and formation of tight junctions.
517
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost
Michael H. Roh,Olga Makarova,Chia Jen Liu,Kunyoo Shin,Seonok Lee,Stephanie Laurinec,Meera Goyal,Roger C. Wiggins,Ben Margolis,Ben Margolis +9 more
TL;DR: The data identifies a new multiprotein complex that appears to be evolutionarily conserved and likely plays an important role in protein targeting and cell polarity.
378
The Carboxyl Terminus of Zona Occludens-3 Binds and Recruits a Mammalian Homologue of Discs Lost to Tight Junctions
TL;DR: It is found that the 6thand 8th PDZ domains of PATJ can interact with the carboxyl termini of zona occludens-3 (ZO-3) and claudin 1, respectively, and reciprocal co-immunoprecipitation experiments revealed that full-length ZO- 3 can associate with PATJ.
190
Composition and function of PDZ protein complexes during cell polarization
Michael H. Roh,Ben Margolis +1 more
TL;DR: This review focuses primarily on the current knowledge of the localization and function of PDZ protein complexes in Drosophila epithelia and discusses recent data that enhance the understanding of the homologous protein complexes.
164
Mammalian Crumbs3 is a small transmembrane protein linked to protein associated with Lin-7 (Pals1).
TL;DR: Cloned a full length cDNA for a human paralogue of CRB1 called Crumbs3 (CRB3), a specialized isoform of the Crumbs protein family that is expressed in epithelia and can tie the apical membrane to the tight junction.