Michael H. Handler
Boston Children's Hospital
128 Papers
611 Citations
Michael H. Handler is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Brain tumor. The author has an hindex of 36, co-authored 120 publications. Previous affiliations of Michael H. Handler include University of Colorado Boulder & Oregon Health & Science University.
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Papers
Characterization of Distinct Immunophenotypes across Pediatric Brain Tumor Types
Andrea Griesinger,Diane K. Birks,Diane K. Birks,Andrew M. Donson,Andrew M. Donson,Vladimir Amani,Vladimir Amani,Lindsey M. Hoffman,Lindsey M. Hoffman,Allen Waziri,Michael Wang,Michael Wang,Michael H. Handler,Michael H. Handler,Nicholas K. Foreman,Nicholas K. Foreman +15 more
TL;DR: Cross-tumor comparative analysis demonstrates that different pediatric brain tumor types exhibit distinct immunophenotypes, implying that specific immunotherapeutic approaches may be most effective for each tumor type.
MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
TL;DR: This data indicates that methylation of the DNA‐repair gene O6‐methylguanine‐DNA methyltransferase causes gene silencing in children with GBM and its relationship to survival and temozolomide sensitivity is unclear.
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Antisense targeting of perlecan blocks tumor growth and angiogenesis in vivo.
Bela Sharma,Michael H. Handler,Inge Eichstetter,John M. Whitelock,Matthew A. Nugent,Renato V. Iozzo +5 more
TL;DR: Perlecan is a potent inducer of tumor growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve cancer treatment.
Conformal Radiation Therapy for Pediatric Ependymoma, Chemotherapy for Incompletely Resected Ependymoma, and Observation for Completely Resected, Supratentorial Ependymoma.
Thomas E. Merchant,Anne Bendel,Noah D. Sabin,Peter C. Burger,Dennis W. W. Shaw,Eric L. Chang,Shengjie Wu,Tianni Zhou,David D. Eisenstat,Nicholas K. Foreman,Christine Fuller,Edwina Templeton Anderson,Juliette Hukin,Ching C. Lau,Ian F. Pollack,Fred H. Laningham,Robert H. Lustig,Floyd D. Armstrong,Michael H. Handler,Chris Williams-Hughes,Sandra Kessel,Mehmet Kocak,David W. Ellison,Vijay Ramaswamy +23 more
TL;DR: The EFS for patients with ependymoma younger than 3 years of age who received immediate postoperative CRT and for older patients is similar, and Irradiation should remain the mainstay of care for most subtypes.
A near-fatal complication of endoscopic third ventriculostomy: case report.
TL;DR: A 14-year-old girl with posthemorrhagic hydrocephalus and an infected ventriculopleural shunt is treated for a newly reported life-threatening complication of neuroendoscopy that must be anticipated by any surgeon undertaking such a procedure.
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