Michael Farrell
Ventana Medical Systems
31 Papers
358 Citations
Michael Farrell is an academic researcher from Ventana Medical Systems. The author has contributed to research in topics: Hapten & Molecular beacon. The author has an hindex of 11, co-authored 31 publications.
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Papers
AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival.
Sarah S. Bacus,Deborah A. Altomare,Ljuba Lyass,Dot Chin,Michael Farrell,Katerina Gurova,Andrei V. Gudkov,Joseph R. Testa +7 more
TL;DR: It is suggested that AKT signaling augments resistance to stress-induced apoptosis in breast cancer cells overexpressing HER-2/neu, suggesting a link between AKT activation and stress resistance in HER- 2/neU-overexpressing cells.
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Development of automated brightfield double In Situ hybridization (BDISH) application for HER2 gene and chromosome 17 centromere (CEN 17) for breast carcinomas and an assay performance comparison to manual dual color HER2 fluorescence In Situ hybridization (FISH)
Hiroaki Nitta,Beatrice Hauss-Wegrzyniak,Megan Lehrkamp,Adrian E. Murillo,Fabien Gaire,Michael Farrell,Eric Walk,Frédérique Penault-Llorca,Masafumi Kurosumi,Manfred Dietel,Lin Wang,Lin Wang,Margaret Loftus,Margaret Loftus,James Pettay,James Pettay,Raymond R. Tubbs,Raymond R. Tubbs,Thomas M. Grogan,Thomas M. Grogan +19 more
TL;DR: An automated brightfield double in situ hybridization (BDISH) application for HER2 gene and chromosome 17 centromere (CEN 17) targets was successfully developed and it might be able to replace manual two-color HER2 FISH methods.
Patent
Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest
Christopher Bieniarz,Michael Farrell +1 more
- 20 Dec 2004
TL;DR: In this article, an enzyme-labeled conjugate molecule was used to detect an analyte of interest in the presence of a redox-inactive reductive species and a soluble metal ion.
73
Patent
Haptens, hapten conjugates, compositions thereof and method for their preparation and use
Jerome W. Kosmeder,Mark Lefever,Donald Johnson,Michael Farrell,Zhanna Zhilina,Christopher Bieniarz +5 more
- 01 Nov 2007
TL;DR: In this paper, a method for performing a multiplexed diagnostic assay, such as for two or more different targets in a sample, is described, which consists of contacting the sample with two specific binding moieties that bind specifically to two or different different targets, and at least one of the haptens is an oxazole, pyrazole, thiazole, a nitroaryl compound other than dinitrophenyl.
70
Patent
Method for quantifying biomolecules conjugated to a nanoparticle
Xiao-Bo Chen,Christopher Bieniarz,Michael Farrell +2 more
- 04 May 2007
TL;DR: In this paper, the number of biomolecules per nanoparticle is determined by quantifying the total number of molecules conjugated to a biomolecule and then the biomolecular concentration is determined using spectrophotometric techniques.
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