Michael E. Woods
University of Texas Medical Branch
6 Papers
Michael E. Woods is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Biology & Immune system. The author has an hindex of 6, co-authored 6 publications.
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Papers
Identification of a glycosylated Ehrlichia canis 19-kilodalton major immunoreactive protein with a species-specific serine-rich glycopeptide epitope.
Jere W. McBride,C. Kuyler Doyle,Xiaofeng Zhang,Ana Maria Cardenas,Vsevolod L. Popov,Kimberly A. Nethery,Michael E. Woods +6 more
TL;DR: The gp19 protein was present on reticulate and dense-cored cells, and it was found extracellularly in the fibrillar matrix and associated with the morula membrane, the host cell cytoplasm, and the nucleus.
The Absence of Toll-Like Receptor 4 Signaling in C3H/HeJ Mice Predisposes Them to Overwhelming Rickettsial Infection and Decreased Protective Th1 Responses
TL;DR: It is demonstrated that, while rickettsiae do not contain endotoxic lipopolysaccharide, they nevertheless initiate TLR4-specific immune responses, and these responses are important in protection.
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Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo
TL;DR: An important role for DCs is revealed in recognizing rickettsiae through TLR4 and inducing early antirickettsial immunity, particularly that conferred by TLR 4-stimulated DCs.
Rickettsiae-stimulated dendritic cells mediate protection against lethal rickettsial challenge in an animal model of spotted fever rickettsiosis
TL;DR: The data suggest that a vigorous proinflammatory response in DCs is associated with protective immunity to rickettsiae and that generation of antigen-specific immunity is crucial to complete protection.
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Nitric Oxide as a Mediator of Increased Microvascular Permeability during Acute Rickettsioses
TL;DR: The data presented support the idea that nitric oxide produced by infected endothelial cells may be contributing to the changes in vascular permeability that occur during acute rickettsioses.
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