Michael E. Todhunter
University of California, San Francisco
16 Papers
87 Citations
Michael E. Todhunter is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 8, co-authored 12 publications. Previous affiliations of Michael E. Todhunter include City of Hope National Medical Center & University of California.
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Papers
Programmed synthesis of three-dimensional tissues
Michael E. Todhunter,Noel Y. Jee,Alex J. Hughes,Maxwell C. Coyle,Alec E. Cerchiari,Justin Farlow,James C. Garbe,James C. Garbe,Mark A. LaBarge,Tejal A. Desai,Zev J. Gartner +10 more
TL;DR: DNA-programmed assembly of cells (DPAC), a method to reconstitute the multicellular organization of organoid-like tissues having programmed size, shape, composition and spatial heterogeneity, is described and used to explore the impact of ECM composition, heterotypic cell-cell interactions and patterns of signaling heterogeneity on collective cell behaviors.
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities
Sisi Chen,Andrew W. Bremer,Olivia Scheideler,Yun Suk Na,Michael E. Todhunter,Sonny C. Hsiao,Prithvi R. Bomdica,Michel M. Maharbiz,Zev J. Gartner,David V. Schaffer +9 more
TL;DR: The platform is used to study the dynamics of single adult neural stem cell fate decisions in response to competing juxtacrine signals and suggests a potential signalling hierarchy between Delta-like 1 and ephrin-B2 ligands.
Not all quiet on the noise front.
Emma McCullagh,Justin Farlow,Chris R. Fuller,Juliet R. Girard,Joanna Lipinski-Kruszka,Dan Lu,Thomas R. Noriega,Geoffrey C. Rollins,Russell Spitzer,Michael E. Todhunter,Hana El-Samad +10 more
TL;DR: The field of study concerned with the investigation of nongenetic individuality, also known as the 'biology of noise', is ripe with exciting scientific opportunities and challenges.
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Formation of Spatially and Geometrically Controlled Three-Dimensional Tissues in Soft Gels by Sacrificial Micromolding
Alec E. Cerchiari,Alec E. Cerchiari,James C. Garbe,Michael E. Todhunter,Noel Y. Jee,James R. Pinney,James R. Pinney,Mark A. LaBarge,Tejal A. Desai,Tejal A. Desai,Zev J. Gartner +10 more
TL;DR: It is demonstrated that Sacrificial Micromolding promotes cyst formation and proper polarization of established epithelial cell lines, allows reconstitution of heterotypic cell-cell interactions in multicomponent epithelia, and can be used to control the lumenization-state of epithelial cysts as a function of tissue size.
Patent
Reprogramming of cellular adhesion
Jennifer S. Liu,Zev J. Gartner,Nicholas S. Selden,Michael E. Todhunter,Samantha Isabel Liang,Robert J. Weber,Noel Youngho Jee +6 more
- 01 Nov 2012
TL;DR: In this article, the processes for the synthesis of these compounds, compositions comprising such compounds, and the use of such compounds and compositions in research and therapeutic applications are discussed, as well as their applications.
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