Michael Doyle

TL;DR: In this paper, the authors proposed methods for enhancing the immune response to vaccination in animals, including humans, comprising administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days post-vaccination.

TL;DR: Small-molecule Cagalpha inhibitors, the first described inhibitors of a TFSS, are potential candidates for the development of new antibacterial compounds that may lead to alternative medical treatments, since they target virulence functions.

TL;DR: Protein uPA receptor antagonists were tested in an in vivo tumor model using the human breast carcinoma MDAmb231 in immunodeficient mice and showed significant inhibition of primary tumor growth, demonstrating that in vivo, both tumor and stromal cell u PA receptor dependent plasminogen activation can modulate tumor growth.

TL;DR: It is believed that this strategy, which requires neither purification nor prior knowledge of a particular target receptor, will prove to be generally useful for identifying peptide ligands that influence cellular function.