Michael Delacher

TL;DR: This article identified a population of tissue-like Treg cells in human peripheral blood that expressed BATF, chemokine receptor CCR8 and HLA-DR, and shared features with nonlymphoid T follicular helper-like (Tfh-like) cells.

TL;DR: It is shown that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and massive invasion of pro-inflammatory macrophages in brown adipose tissue.

TL;DR: A regulatory role for TCF7 is proposed in limiting access to the Treg lineage by influencing the required TCR signaling strength of Treg precursors and broadening the repertoire and allowed lower TCR affinities to be recruited into the T Reg lineage.

TL;DR: Recent progress in understanding how Foxp3 expression itself is epigenetically and transcriptionally controlled, how the Treg-specific signature is achieved and how unique properties of Treg subsets are defined by other transcription factors is summarized.