Michael D. Street
Royal Children's Hospital
7 Papers
175 Citations
Michael D. Street is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: CTL* & Antigen. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Michael D. Street include University of Queensland.
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Papers
•Journal Article
Peripheral Tolerance to Human Papillomavirus E7 Oncoprotein Occurs by Cross-Tolerization, Is Largely Th-2-independent, and Is Broken by Dendritic Cell Immunization
Tracy Doan,Karen A. Herd,Paul F. Lambert,Germain J. P. Fernando,Michael D. Street,Robert W. Tindle +5 more
TL;DR: It is demonstrated that tolerization of E7-directed pCTLs occurs within 2 weeks of exposure to E7 in epithelium and is maintained in the near absence of CD4+ cells and in the absence of the thymus, and is independent of a coexisting E8-directed Th2-type antibody response.
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Mice Expressing the E7 Oncogene of HPV16 in Epithelium Show Central Tolerance, and Evidence of Peripheral Anergising Tolerance, to E7-Encoded Cytotoxic T-Lymphocyte Epitopes
Tracy Doan,Melita Chambers,Michael D. Street,Germain J. P. Fernando,Karen A. Herd,Paul F. Lambert,Robert W. Tindle +6 more
TL;DR: In agreement with these in vitro findings, specific immunisation failed to significantly alter the course of E7-associated tumour development in K14E7 x A2.1 mice, consistent with a model of central deletional CTL tolerance to E6-encoded epitopes recognised in the context of two distinct MHC class 1 restriction elements, and with the possibility of peripheral T-cell anergy maintained by expression of E6 in the skin.
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Human papillomavirus type 16 E7 oncoprotein expressed in peripheral epithelium tolerizes E7-directed cytotoxic T-lymphocyte precursors restricted through human (and mouse) major histocompatibility complex class I alleles.
Tracy Doan,Karen A. Herd,Michael D. Street,Gregory Bryson,Germain J. P. Fernando,Paul F. Lambert,Robert W. Tindle +6 more
TL;DR: It is demonstrated that E7 protein expression in peripheral squamous epithelium is sufficient to tolerize the E7-directed CTL precursor repertoire, and this data has implications for E6-mediated tumorigenesis and for the development of E8-based immunotherapeutic strategies.
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Limitations of HLA-transgenic mice in presentation of HLA-restricted cytotoxic T-cell epitopes from endogenously processed human papillomavirus type 16 E7 protein.
TL;DR: There are generic implications for the universal applicability of HLA‐class 1 transgenic mice for studies of human CTL epitope presentation in murine models of human infectious disease where recognition of endogenously processed antigen is necessary.
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Nonspecific Down-Regulation of CD8+T-Cell Responses in Mice Expressing Human Papillomavirus Type 16 E7 Oncoprotein from the Keratin-14 Promoter
Robert W. Tindle,Karen A. Herd,Tracy Doan,Greg Bryson,Graham R. Leggatt,Paul F. Lambert,Ian H. Frazer,Michael D. Street +7 more
TL;DR: Doan et al. as mentioned in this paper quantified major histocompatibility complex class I tetramer-binding T cells and CTL in mice expressing an HPV16 E7 transgene from the keratin-14 (K14) promoter in basal and suprabasal keratinocytes and in thymic cortical epithelium.
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