Michael D. Fellows
AstraZeneca
13 Papers
44 Citations
Michael D. Fellows is an academic researcher from AstraZeneca. The author has contributed to research in topics: Micronucleus test & Genotoxicity. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of Michael D. Fellows include Loughborough University.
Chat about Author
Papers
Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up meeting of the international workshop on Genotoxicity testing—Aberdeen, Scotland, 2003—Assay acceptance criteria, positive controls, and data evaluation
Martha M. Moore,Masamitsu Honma,Julie Clements,George Bolcsfoldi,Brian Burlinson,Maria A. Cifone,Jane Clarke,Robert R. Delongchamp,Robert Durward,Michael D. Fellows,B. Bhaskar Gollapudi,Sai-Mei Hou,Peter Jenkinson,Melvin Lloyd,Jenness B. Majeska,Brian Myhr,Michael R. O’Donovan,Takashi Omori,Colin Riach,Richard H.C. San,Leon F. Stankowski,Ajit K. Thakur,Freddy Van Goethem,Shinobu Wakuri,Isao Yoshimura +24 more
TL;DR: The Mouse Lymphoma Assay (MLA) Workgroup reached consensus on the acceptance criteria for both the agar and microwell versions of the MLA and on criteria to define an acceptable positive control response.
152
Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000.
Martha M. Moore,Masamitsu Honma,Julie Clements,Karen Harrington-Brock,Takumi Awogi,George Bolcsfoldi,Maria A. Cifone,Deborah D. Collard,Michael D. Fellows,Kathryn Flanders,B. Bhaskar Gollapudi,Peter Jenkinson,Paul Kirby,Stephan Kirchner,Joann Kraycer,Stephen McEnaney,Wolfgang Muster,Brian Myhr,Michael R. O’Donovan,Jo Oliver,Marie-Claude Ouldelhkim,Kamala Pant,Robert Preston,Colin Riach,Richard H.C. San,Hiroyasu Shimada,Leon F. Stankowski +26 more
TL;DR: The Mouse Lymphoma Assay Workgroup of the International Workshop on Genotoxicity Test Procedures held a second harmonization meeting just prior to the U.S. Environmental Mutagen Society Meeting in New Orleans, LA, in April 2000 and unanimously agreed that the relative total growth (RTG) should be used as the cytotoxicity measure for concentration selection and data evaluation.
75
Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it
TL;DR: It was shown that, for a variety of agents with differing modes of action, cytotoxicity varies considerably depending on the method used to estimate it, and that trypan blue exclusion, MI and binucleate incidence all grossly underestimate cytot toxicity in comparison with cell growth or CE.
65
Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment.
Martha M. Moore,Masamitsu Honma,Julie Clements,George Bolcsfoldi,Brian Burlinson,Maria A. Cifone,Jane Clarke,Philip Clay,Rupa S. Doppalapudi,Michael D. Fellows,B. Bhaskar Gollapudi,Sai-Mei Hou,Peter Jenkinson,Wolfgang Muster,Kamala Pant,Darren Kidd,Elisabeth Lorge,Melvyn Lloyd,Brian Myhr,Michael R. O’Donovan,Colin Riach,Leon F. Stankowski,Ajit K. Thakur,Freddy Van Goethem +23 more
TL;DR: The Mouse Lymphoma Assay (MLA) Workgroup of the International Workshop on Genotoxicity Testing (IWGT), comprised of experts from Japan, Europe and the United States, met on September 9, 2005, in San Francisco, USA, to reach a consensus on issues involved with 24-h treatment.
62
In vivo genotoxicity studies with 3-monochloropropan-1,2-diol.
TL;DR: Results from two in vivo mutagenicity studies with 3-MCPD are presented, namely a bone marrow micronucleus test in the rat and unscheduled DNA synthesis in theRat liver, both conducted in accordance with relevant OECD protocols, showing that 3- MCPD does not possess genotoxic activity in vivo in the tissues examined.