Michael C. Velarde
University of the Philippines Diliman
56 Papers
365 Citations
Michael C. Velarde is an academic researcher from University of the Philippines Diliman. The author has contributed to research in topics: Biology & KLF9. The author has an hindex of 26, co-authored 51 publications. Previous affiliations of Michael C. Velarde include University of the Philippines & Buck Institute for Research on Aging.
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Papers
Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype
Christopher D. Wiley,Michael C. Velarde,Pacome Lecot,Su Liu,Ethan A. Sarnoski,Adam Freund,Kotaro Shirakawa,Hyung W. Lim,Sonnet S. Davis,Arvind Ramanathan,Akos A. Gerencser,Eric Verdin,Judith Campisi,Judith Campisi +13 more
TL;DR: It is shown that several manipulations that compromise mitochondrial function in proliferating human cells induce a senescence growth arrest with a modified SASP that lacks the IL-1-dependent inflammatory arm, providing a mechanism by which mitochondrial dysfunction can drive aging phenotypes.
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Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging.
TL;DR: The role of mitochondrial reactive oxygen species (ROS), mitochondrial dynamics (fission and fusion), the electron transport chain (ETC), bioenergetic balance, redox state, metabolic signature, and calcium homeostasis in controlling cellular growth arrest are discussed.
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Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin
Michael C. Velarde,James M. Flynn,Nicholas U. Day,Simon Melov,Judith Campisi +4 more
- 20 Jan 2012
TL;DR: It is shown that the number of senescent cells, as well as impaired mitochondrial (complex II) activity increase in naturally aged mouse skin, and the idea that mitochondrial oxidative stress and cellular senescence contribute to aging skin phenotypes in vivo is supported.
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Placental membrane aging and HMGB1 signaling associated with human parturition.
Ramkumar Menon,Faranak Behnia,Jossimara Polettini,George R. Saade,Judith Campisi,Michael C. Velarde,Michael C. Velarde +6 more
- 04 Feb 2016
TL;DR: Data suggest that the natural physiologic aging of placental tissues is associated with cellular senescence and human parturition, and shows that recombinant HMGB1 upregulates the expression of genes associated with parturitions in myometrial cells.
Senescent cells and their secretory phenotype as targets for cancer therapy
Michael C. Velarde,Marco Demaria,Judith Campisi +2 more
- 17 Jan 2013
TL;DR: The beneficial and detrimental effects of inducing cellular senescence are discussed, strategies for targeting senescent cells as a means to fight cancer are proposed, and the deleterious effects ofSenescence-associated secretory phenotype or SASP are discussed.
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