Michael C. Frühwald
University of Münster
17 Papers
180 Citations
Michael C. Frühwald is an academic researcher from University of Münster. The author has contributed to research in topics: DNA methylation & CpG site. The author has an hindex of 14, co-authored 17 publications. Previous affiliations of Michael C. Frühwald include University of Würzburg & University of Southern California.
Chat about Author
Papers
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
Joseph F. Costello,Joseph F. Costello,Michael C. Frühwald,Michael C. Frühwald,Dominic J. Smiraglia,Laura J. Rush,Gavin P. Robertson,Xin Gao,Fred A. Wright,Jamison D. Feramisco,Päivi Peltomäki,James C. Lang,David E. Schuller,Li Yu,Clara D. Bloomfield,Michael A. Caligiuri,Allan J. Yates,Ryo Nishikawa,H.-J. Su Huang,Nicholas J. Petrelli,Xueli Zhang,M. S. O'Dorisio,William A. Held,Webster K. Cavenee,Webster K. Cavenee,Christoph Plass +25 more
TL;DR: This report reports a global analysis of the methylation status of 1,184 unselected CpG islands in each of 98 primary human tumours using restriction landmark genomic scanning (RLGS), and estimates that an average of 600 C pG islands were aberrantly methylated in the tumours, including early stage tumours.
1.5K
Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies
Dominic J. Smiraglia,Laura J. Rush,Michael C. Frühwald,Michael C. Frühwald,Zunyan Dai,William A. Held,Joseph F. Costello,James C. Lang,Charis Eng,Bin Li,Fred A. Wright,Michael A. Caligiuri,Christoph Plass +12 more
TL;DR: Data indicate that most CpG island hypermethylation observed in cancer cell lines is due to an intrinsic property of cell lines as opposed to the malignant tissue from which they originated.
Nonsense Mutation and Inactivation of SMARCA4 (BRG1) in an Atypical Teratoid/Rhabdoid Tumor Showing Retained SMARCB1 (INI1) Expression
Martin Hasselblatt,Stefan Gesk,Florian Oyen,Sabrina Rossi,Elisabetta Viscardi,Felice Giangaspero,Felice Giangaspero,Caterina Giannini,Alexander R. Judkins,Alexander R. Judkins,Michael C. Frühwald,Tobias Obser,Reinhard Schneppenheim,Reiner Siebert,Werner Paulus +14 more
TL;DR: The case of a supratentorial AT/RT in a 9-month-old boy, which showed retained SMARCB1 staining on immunohistochemistry and lacked genetic alterations of SMarCB1, highlights the role of SMARCA4 in the pathogenesis of SM ARCB1-positive At/RT and the usefulness of antibodies directed against SMAR CA4 in this diagnostic setting.
243
Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas--implications for tumor biology and potential clinical utility.
Michael C. Frühwald,Michael C. Frühwald,M. Sue O'Dorisio,M. Sue O'Dorisio,Zunyan Dai,Stephan M. Tanner,Douglas A. Balster,Douglas A. Balster,Xin Gao,Fred A. Wright,Christoph Plass +10 more
TL;DR: It is suggested that DNA hypermethylation has an outstanding potential for the identification of novel tumor suppressors as well as diagnostic and therapeutic targets in MBs and other PNETs of the CNS.
100
Tissue specific DNA methylation of CpG islands in normal human adult somatic tissues distinguishes neural from non-neural tissues
Srimoyee Ghosh,Allan J. Yates,Michael C. Frühwald,Jeffrey C. Miecznikowski,Christoph Plass,Dominic J. Smiraglia +5 more
TL;DR: Tissue specific methylation for certain CpG islands was demonstrated, with clear differences between white and grey matter of the brain, and there was an overall pattern of tissue specifically methylated C pG islands that distinguished neural tissues from non-neural.
97