Michael Buschle
Intercell
10 Papers
134 Citations
Michael Buschle is an academic researcher from Intercell. The author has contributed to research in topics: Immune system & Adjuvant. The author has an hindex of 9, co-authored 10 publications.
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Papers
IC31, a novel adjuvant signaling via TLR9, induces potent cellular and humoral immune responses.
Carola Schellack,Karin Prinz,Alena Egyed,Jörg H. Fritz,Barbara Wittmann,Michael Ginzler,Gabriele Swatosch,Wolfgang Zauner,Constantia Kast,Shizuo Akira,Alexander von Gabain,Michael Buschle,Karen Lingnau +12 more
TL;DR: Activation of murine dendritic cells by IC31 induced efficiently proliferation of naïve CD4(+) TCR transgenic T cells as well as their differentiation into IFN-gamma- and IL-4-producing T cells in vitro.
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Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41.
Christoph Klade,Heiner Wedemeyer,Thomas Berg,Holger Hinrichsen,Grazyna Cholewinska,Stefan Zeuzem,Hubert E. Blum,Michael Buschle,Sandra Jelovcan,Vera Buerger,Erich Tauber,Juergen Frisch,Michael P. Manns +12 more
TL;DR: This study showed that the HCV peptide vaccine IC41 can induce HCV-specific Th1/Tc1 responses in a subset of difficult to treat HCV nonresponder patients despite persisting viremia.
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The artificial antimicrobial peptide KLKLLLLLKLK induces predominantly a TH2-type immune response to co-injected antigens.
Jörg H. Fritz,Sylvia Brunner,Max L Birnstiel,Michael Buschle,Alexander von Gabain,Frank Mattner,Wolfgang Zauner +6 more
TL;DR: It is shown that KLKL5KLK induces a sustained immune response with a prevalent TH2 profile when co-injected with proteinaceous and peptide-based antigens, making it an interesting adjuvant for novel vaccine design.
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PIBF (progesterone induced blocking factor) is overexpressed in highly proliferating cells and associated with the centrosome
Margit Lachmann,Dieter Gelbmann,Endre Kálmán,Beata Polgar,Michael Buschle,Alexander von Gabain,Julia Szekeres-Bartho,Julia Szekeres-Bartho,Eszter Nagy +8 more
TL;DR: RNA expression analyses of several human cell lines with different tissue origin and paired human tumor/normal tissues revealed that PIBF mRNA was overexpressed in highly proliferating cells independent of the presence of PR, revealing a strong parallel with known tumor suppressor proteins, such as BRCA1 and p53 having the same centrosomal localization.
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Small-fragment genomic libraries for the display of putative epitopes from clinically significant pathogens.
Tamás Henics,Birgit Winkler,U. Pfeifer,Steven R. Gill,Michael Buschle,A. von Gabain,Andreas Meinke +6 more
TL;DR: This procedure relies on highly representative small-fragment genomic libraries that are expressed to display frame-selected epitope-size peptides on a bacterial cell surface and to interact directly with carefully selected disease-relevant high-titer sera.
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