Michael Bula
Picower Institute for Learning and Memory
7 Papers
8 Citations
Michael Bula is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Biology & Neurodegeneration. The author has an hindex of 2, co-authored 3 publications. Previous affiliations of Michael Bula include Massachusetts Institute of Technology.
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Papers
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
Joel W. Blanchard,Leyla Anne Akay,Jose Davila-Velderrain,Djuna von Maydell,Hansruedi Mathys,Shawn M. Davidson,Audrey H. Effenberger,Chih-Yu Chen,Kristal M. Maner-Smith,Ihab Hajjar,Eric A. Ortlund,Michael Bula,Emre Agbas,Ayesha P. Ng,Xueqiao Jiang,Martin Kahn,C Blanco-Duque,Nicolas Lavoie,Liwang Liu,Ricardo Reyes,Yuan-Ta Lin,Tak Ko,Lea R'Bibo,William T. Ralvenius,David A. Bennett,Hugh P. Cam,Manolis Kellis,Li-Huei Tsai +27 more
TL;DR: In this article , a single-cell transcriptomics profiling of post-mortem human brains from APOE4 carriers compared with non-carriers was performed to gain more comprehensive insights into the impact of APOE-4 on the human brain.
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Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes.
Joel W. Blanchard,Michael Bula,Michael Bula,Jose Davila-Velderrain,Leyla Anne Akay,Leyla Anne Akay,Lena Zhu,Lena Zhu,Alexander Frank,Alexander Frank,Matheus B. Victor,Matheus B. Victor,Julia Maeve Bonner,Julia Maeve Bonner,Hansruedi Mathys,Hansruedi Mathys,Hansruedi Mathys,Yuan-Ta Lin,Yuan-Ta Lin,Tak Ko,David A. Bennett,Hugh P. Cam,Hugh P. Cam,Manolis Kellis,Manolis Kellis,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +27 more
TL;DR: An iPSC-based three-dimensional model of the human blood–brain barrier reveals that NFAT and APOE dysregulation in pericyte-like mural cells contributes to cerebral amyloid angiopathy and can potentially be targeted to treat Alzheimer’s disease.
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A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.
Ping-Chieh Pao,Jinsoo Seo,Audrey Lee,Oleg Kritskiy,Debasis Patnaik,Jay Penney,Ravikiran M. Raju,Ute Geigenmuller,M. Catarina Silva,Diane Lucente,James F. Gusella,Bradford C. Dickerson,Anjanet R. Loon,Michael Bula,Stephen J. Haggarty,Li-Huei Tsai +15 more
TL;DR: A 12-amino acid-long peptide fragment derived from cyclin-dependent kinase (Cdk5i) was reported in this article , which showed high binding affinity toward the Cdk5/p25 complex, disrupts the interaction of Cdk-5 with p25, and lowers Cdk 5/p 25 kinase activity.
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Proteomic profiling dataset of chemical perturbations in multiple biological backgrounds.
Deborah Dele-Oni,Karen E. Christianson,Shawn Egri,Alvaro Sebastian Vaca Jacome,Katherine C. DeRuff,James Mullahoo,Vagisha Sharma,Desiree Davison,Tak Ko,Michael Bula,Joel W. Blanchard,Jennie Z. Young,Lev Litichevskiy,Xiaodong Lu,Daniel D. Lam,Jacob K. Asiedu,Caidin Toder,Adam Officer,Ryan Peckner,Michael J. MacCoss,Li-Huei Tsai,Steven A. Carr,Malvina Papanastasiou,Jacob D. Jaffe +23 more
TL;DR: The Global Chromatin Profiling (GCP) dataset as mentioned in this paper contains profiles from a new set of cardiotoxic compounds and from astrocytes, an additional neural cell model.
A cyclin-dependent kinase 5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes
Jinsoo Seo,Ping-Chieh Pao,Oleg Kritskiy,Audrey Lee,Debasis Patnaik,L Ashley Watson,Michael Bula,Scarlett J. Barker,Jay Penney,M. Catarina Silva,Stephen J. Haggarty,Li-Huei Tsai +11 more
TL;DR: Using cellular assays, mouse neurodegeneration models and human cerebral organoids generated from patient-derived iPSCs, beneficial effects of the Cdk5i peptide on various pathological phenotypes including gliosis, DNA damage, and Tau hyperphosphorylation are demonstrated.