Michael Bui
University of Alberta
5 Papers
Michael Bui is an academic researcher from University of Alberta. The author has contributed to research in topics: Endoplasmic reticulum & Biology. The author has an hindex of 5, co-authored 5 publications.
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Papers
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress
Roberto Bravo,Jose Miguel Vicencio,Jose Miguel Vicencio,Valentina Parra,Rodrigo Troncoso,Juan Pablo Muñoz,Michael Bui,Clara Quiroga,Andrea E. Rodriguez,Hugo Verdejo,Hugo Verdejo,Jorge Ferreira,Myriam Iglewski,Mario Chiong,Thomas Simmen,Antonio Zorzano,Joseph A. Hill,Beverly A. Rothermel,Gyorgy Szabadkai,Sergio Lavandero,Sergio Lavandero +20 more
TL;DR: It is shown that, during the onset of ER stress, the reticular and mitochondrial networks are redistributed towards the perinuclear area and their points of connection are increased in a microtubule-dependent fashion, which establishes the metabolic basis for the adaptation to this response.
Palmitoylated TMX and calnexin target to the mitochondria-associated membrane.
Emily M. Lynes,Michael Bui,Megan C. Yap,Matthew D. Benson,Bobbie L. Schneider,Lars Ellgaard,Luc G. Berthiaume,Thomas Simmen +7 more
TL;DR: This work demonstrates that palmitoylation of cysteine residue(s) adjacent to the membrane‐spanning domain promotes MAM enrichment of the transmembrane thioredoxin family protein TMX and shows that calnexin shuttles between the rough ER and the MAM depending on its palMIToylation status.
Rab32 modulates apoptosis onset and Mitochondria-associated Membrane (MAM) properties
Michael Bui,Susanna Y. Gilady,Ross E. B. Fitzsimmons,Matthew D. Benson,Emily M. Lynes,Kevin Gesson,Neal M. Alto,Stefan Strack,John D. Scott,Thomas Simmen +9 more
TL;DR: Through a combination of its functions as a PKA-anchoring protein and a regulator of MAM properties, the activity and expression level of Rab32 determine the speed of apoptosis onset.
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•Journal Article
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress (vol 124, pg 2143, 2011)
Roberto Bravo,Jose Miguel Vicencio,Parra,Rodrigo Troncoso,Juan Pablo Muñoz,Michael Bui,Clara Quiroga,Andrea E. Rodriguez,Hugo Verdejo,Jorge Ferreira,Myriam Iglewski,Mario Chiong,Thomas Simmen,Antonio Zorzano,Joseph A. Hill,Beverly A. Rothermel,Gyorgy Szabadkai,Sergio Lavandero +17 more
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Ero1α requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM)
Susanna Y. Gilady,Michael Bui,Emily M. Lynes,Matthew D. Benson,Russell Watts,Jean E. Vance,Thomas Simmen +6 more
TL;DR: The results show that within the ER, Ero1α is almost exclusively found on the mitochondria-associated membrane (MAM), and the localization of Ero2α on the MAM is dependent on oxidizing conditions within theER, which requires normoxic conditions, but not ongoing oxidative phosphorylation.