Michael Brunner
University of Freiburg
68 Papers
435 Citations
Michael Brunner is an academic researcher from University of Freiburg. The author has contributed to research in topics: Long QT syndrome & QT interval. The author has an hindex of 19, co-authored 64 publications. Previous affiliations of Michael Brunner include University of Vienna & University Medical Center Freiburg.
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Papers
Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome
Michael Brunner,Xuwen Peng,Gongxin Liu,Xiao-Qin Ren,Ohad Ziv,Bum-Rak Choi,Rajesh Mathur,Mohammed Hajjiri,Katja E. Odening,Eric Steinberg,Eduardo J. Folco,Ekatherini Pringa,Jason Centracchio,Roland Macharzina,Tammy Donahay,Lorraine Schofield,Naveed Rana,Malcolm Kirk,Gary F. Mitchell,Athena Poppas,Manfred Zehender,Gideon Koren,Gideon Koren +22 more
TL;DR: The elimination of 1 repolarizing current was associated with downregulation of the reciprocal repolarization current rather than with the compensatory upregulation observed previously in LQTS mouse models, which suggests that mutant KvLQT1 and HERG interacted with the reciprocal wild-type alpha subunits of rabbit ERG and Kv LQT 1, respectively.
Long-term survival after pacemaker implantation. Prognostic importance of gender and baseline patient characteristics.
TL;DR: Survival of patients with pacemakers is independently influenced by several baseline characteristics which can identify patients with very long survival, as revealed by multivariate analysis.
144
Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective.
Katja E. Odening,Bum-Rak Choi,Gongxin Liu,Kathryn M Hartmann,Ohad Ziv,Leonard Chaves,Lorraine Schofield,Jason Centracchio,Manfred Zehender,Xuwen Peng,Michael Brunner,Gideon Koren +11 more
TL;DR: This study reveals the proarrhythmic effect of EST and the antiarrhythmic effect of PROG in LQT2 in vivo, outlining a new potential antiarrHythmic therapy for LQTS.
124
Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization
Katja E. Odening,Omar Hyder,Leonard Chaves,Lorraine Schofield,Michael Brunner,Malcolm Kirk,Manfred Zehender,Xuwen Peng,Gideon Koren,Gideon Koren +9 more
TL;DR: Transgenic LQT1 and LqT2 rabbits could serve as an in vivo model in which to examine the pharmacogenomics of drug-induced QT prolongation of anesthetic agents and their proarrhythmic potential.
83
On the emerging role of rabbit as human disease model and the instrumental role of novel transgenic tools
Véronique Duranthon,Nathalie Beaujean,Michael Brunner,Katja E. Odening,A. Navarrete Santos,Imre Kacskovics,László Hiripi,E J Weinstein,Zsuzsanna Bosze +8 more
TL;DR: The first transgenic rabbits models of arrhythmogenesis mimic human cardiac diseases much better than transgenic mice and hereby underline the importance of non-mouse models.
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