Michael Biddle
University of Leicester
8 Papers
31 Citations
Michael Biddle is an academic researcher from University of Leicester. The author has contributed to research in topics: Myofibroblast & Fevipiprant. The author has an hindex of 4, co-authored 7 publications.
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Papers
Stressed out - The role of oxidative stress in airway smooth muscle dysfunction in asthma and COPD.
TL;DR: A thorough review of studies that have used primary airway, bronchial or tracheal smooth muscle cells to investigate the role of oxidative stress/ROS in ASM dysfunction and consider how they could contribute to the pathophysiology of asthma and COPD is provided in this paper .
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Increased β2‐adrenoceptor phosphorylation in airway smooth muscle in severe asthma: possible role of mast cell‐derived growth factors
Latifa Chachi,Abdulrahman Alzahrani,Abdulrahman Alzahrani,Cynthia Koziol-White,Michael Biddle,Rehab Bagadood,Reynold A. Panettieri,Peter Bradding,Yassine Amrani +8 more
TL;DR: This study shows for the first time that abnormal β2‐AR phosphorylation/function in ASM cells that is induced rapidly by HLMC‐derived growth factors, is present constitutively in cells from severe asthmatics.
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TGFβ1 induces resistance of human lung myofibroblasts to cell death via down-regulation of TRPA1 channels
Harvinder Virk,Michael Biddle,Dawn T. Smallwood,Cathryn Weston,E Castells,Viona W. Bowman,Jamie McCarthy,Yassine Amrani,S. Mark Duffy,Peter Bradding,Katy M. Roach +10 more
TL;DR: In this paper, the authors investigated the involvement of redox-sensitive TRPA1 ion channels on human lung myofibroblasts (HLMFs) cell death and TGFβ1-mediated pro-fibrotic responses.
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Fevipiprant (qaw039) Reduces Airway Smooth Muscle Mass In Asthma Via Antagonism Of The Prostaglandin D2 Receptor 2 (dp2)
Ruth Saunders,Himanshu Kaul,Rachid Berair,Amisha Singapuri,I Chernyaysky,Latifa Chachi,Michael Biddle,Amanda Sutcliffe,M Laurencin,Gerald Bacher,Michelle Bourne,Ian D. Pavord,Andrew J. Wardlaw,Salman Siddiqui,Richard Kay,Bindi S. Brook,Rod Smallwood,C E Brightling +17 more
- 01 Jan 2017
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DP2/CRTh2 is expressed by ASM cells in asthma and its inhibition suppresses ASM migration
Ruth Saunders,Michael Biddle,Adam K. A. Wright,Latifa Chachi,Amanda Sutcliffe,Rachid Berair,Christopher E. Brightling +6 more
TL;DR: ASM-derived PGD2 may play a role in promoting ASM migration and could contribute to increased ASM mass in asthma.
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