Michael B. Ware
Emory University
8 Papers
6 Citations
Michael B. Ware is an academic researcher from Emory University. The author has contributed to research in topics: Pancreatic cancer & Immune system. The author has an hindex of 4, co-authored 8 publications.
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Papers
Soy isoflavones and their metabolites modulate cytokine-induced natural killer cell function.
Thomas A. Mace,Michael B. Ware,Samantha King,Shannon Loftus,Matthew R. Farren,Elizabeth L. McMichael,Steven D. Scoville,Connor Geraghty,Gregory S. Young,William E. Carson,Steven K. Clinton,Gregory B. Lesinski +11 more
TL;DR: In vivo studies revealed that C57BL/6 mice fed a soy-enriched diet produce less plasma IFN-γ following administration of IL-12/IL-18 versus control-fed animals, providing insight into how dietary soy modulates NK cell functions.
Mirage or long-awaited oasis: reinvigorating T-cell responses in pancreatic cancer.
TL;DR: This review will highlight recent advances in the field related to immune suppression in PDAC, emerging preclinical data and rationale for ongoing immunotherapy clinical trials and encourage development of novel therapeutics to improve T-cell responses in this challenging disease.
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Dual blockade of IL-6 and CTLA-4 regresses pancreatic tumors in a CD4+ T-cell-dependent manner.
Michael B. Ware,Christopher McQuinn,Mohammad Y. Zaidi,Hannah M. Knochelmann,Robinson B,Cameron Herting,Thomas A. Mace,Zhengjia Chen,Chi Zhang,Matthew R. Farren,Amanda Ruggieri,Jacob S. Bowers,Reena Shakya,Gregory S. Young,Bassel F. El-Rayes,Chrystal M. Paulos,Gregory B. Lesinski +16 more
TL;DR: These data represent the first report of IL-6 and CTLA-4 blockade as a means to regress pancreatic tumors with defined operative mechanisms of efficacy and have potential for immediate clinical translation.
Abstract B59: IL-6 regulates CTLA4 expression on CD4+ T-cells and dual antibody blockade of IL-6 and CTLA4 leads to tumor regression in an orthotopic murine model of pancreatic ductal adenocarcinoma
Michael B. Ware,Christopher McQuinn,Thomas A. Mace,Jacob Bowers,Reena Shakya,Brad Farris,Gregory S. Young,William E. Carson,Chrystal M. Paulos,Bassel F. El-Rayes,Gregory B. Lesinski +10 more
TL;DR: The ability of IL-6 to regulate CTLA4 expression on CD4+ T cells, unveiling a new dynamic in PDAC-associated immune suppression, is demonstrated for the first time.
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Abstract 4074: Heat shock protein 90 inhibitors alter pancreatic stellate cell cytokine production and enhances the efficacy of immune checkpoint blockade in pancreatic cancer
Mohammad Y. Zaidi,Yuchen Zhang,Michael B. Ware,Matthew R. Farren,Hannah Komar,Brian Olson,Ganji Purnachandra Nagaraju,Mehmet Akce,Olatunji B. Alese,Shishir K. Maithel,Juan M. Sarmiento,Walid L. Shaib,Christina Wu,Bassel F. El-Rayes,Gregory B. Lesinski +14 more
TL;DR: It is hypothesized that targeting Hsp90 can modulate the TME, through its ability to target inflammatory signaling and cytokine production by PSC and enhance the efficacy of immunotherapy, and completed the dose escalation phase of a Phase Ib/II clinical trial of XL888 (Hsp90i) and pembrolizumab (anti-PD-1) at the authors' institution.
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