Michael Ameismeier
Ludwig Maximilian University of Munich
11 Papers
7 Citations
Michael Ameismeier is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Eukaryotic Small Ribosomal Subunit & Ribosome. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Michael Ameismeier include Center for Integrated Protein Science Munich.
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Papers
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Jan Hendrik Straub,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +17 more
TL;DR: Structural characterization of the inhibitory mechanism of Nsp1 may aid structure-based drug design against SARS-CoV-2 and effectively blocks retinoic acid–inducible gene I–dependent innate immune responses that would otherwise facilitate clearance of the infection.
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Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Matthias Thoms,Robert Buschauer,Michael Ameismeier,Lennart Koepke,Timo Denk,Maximilian Hirschenberger,Hanna Kratzat,Manuel Hayn,Timur Mackens-Kiani,Jingdong Cheng,Christina M. Stürzel,Thomas Fröhlich,Otto Berninghausen,Thomas Becker,Frank Kirchhoff,Konstantin M. J. Sparrer,Roland Beckmann +16 more
TL;DR: It is shown that Nsp1 from SARS-CoV-2 binds to 40S and 80S ribosomes, resulting in shutdown of capped mRNA translation both in vitro and in cells, which effectively blocks RIG-I-dependent innate immune responses that would otherwise facilitate clearance of the infection.
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Symbiosis induces widespread changes in the proteome of the model cnidarian Aiptasia.
Clinton A. Oakley,Michael Ameismeier,Lifeng Peng,Virginia M. Weis,Arthur R. Grossman,Simon K. Davy +5 more
TL;DR: This work utilized label‐free liquid chromatography electrospray‐ionization tandem mass spectrometry to analyze the effects of symbiosis on the proteomes of symbiotic and aposymbiotic Aiptasia, and identified and obtained relative quantification of more than 3,300 proteins in 1,578 protein clusters.
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90S pre-ribosome transformation into the primordial 40S subunit
Jingdong Cheng,Benjamin Lau,Giuseppe La Venuta,Michael Ameismeier,Otto Berninghausen,Ed Hurt,Roland Beckmann +6 more
TL;DR: These studies reveal how a cast of molecular players act to coordinate the compositional and structural changes that transform the 90S preribosome into a pre-40S subunit and clarify the principles of assembly and remodeling of large ribonucleoproteins.
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A structural inventory of native ribosomal ABCE1‐43S pre‐initiation complexes
Hanna Kratzat,Timur Mackens-Kiani,Michael Ameismeier,Mia Potocnjak,Jingdong Cheng,Estelle Dacheux,Abdelkader Namane,Otto Berninghausen,Franz Herzog,Micheline Fromont-Racine,Thomas Becker,Roland Beckmann +11 more
TL;DR: The native human samples provide a near‐complete molecular picture of the architecture and sophisticated interaction network of the 43S‐bound eIF3 complex and the eIF2 ternary complex containing the initiator tRNA.
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