Michael A. Mahowald
Washington University in St. Louis
17 Papers
164 Citations
Michael A. Mahowald is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Biology & Health Administration Informatics. The author has an hindex of 11, co-authored 17 publications. Previous affiliations of Michael A. Mahowald include University of Chicago & Harvard University.
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Papers
An obesity-associated gut microbiome with increased capacity for energy harvest
Peter J. Turnbaugh,Ruth E. Ley,Michael A. Mahowald,Vincent Magrini,Elaine R. Mardis,Jeffrey I. Gordon +5 more
TL;DR: It is demonstrated through metagenomic and biochemical analyses that changes in the relative abundance of the Bacteroidetes and Firmicutes affect the metabolic potential of the mouse gut microbiota and indicates that the obese microbiome has an increased capacity to harvest energy from the diet.
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Reciprocal Gut Microbiota Transplants from Zebrafish and Mice to Germ-free Recipients Reveal Host Habitat Selection
TL;DR: Results reveal that communities are assembled in predictable ways, and differences in community structure between zebrafish and mice arise in part from distinct selective pressures imposed within the gut habitat of each host.
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Helper T Cell Differentiation Is Controlled by the Cell Cycle
Jennifer J. Bird,Daniel R. Brown,Alan C. Mullen,Naomi H. Moskowitz,Michael A. Mahowald,Jenny R. Sider,Thomas F. Gajewski,Chyung Ru Wang,Steven L. Reiner +8 more
TL;DR: Examining gene expression in discrete generations of dividing cells reveals a novel mechanism governing Th cell fate that initially integrates proliferative and differentiative signals and subsequently maintains stability of the differentiated state.
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Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla
Michael A. Mahowald,Federico E. Rey,Henning Seedorf,Peter J. Turnbaugh,Robert S. Fulton,Aye Wollam,Neha Shah,Chunyan Wang,Vincent Magrini,Richard K. Wilson,Brandi L. Cantarel,Brandi L. Cantarel,Pedro M. Coutinho,Bernard Henrissat,Bernard Henrissat,Lara W. Crock,Alison L Russell,Nathan C Verberkmoes,Robert L. Hettich,Jeffrey I. Gordon +19 more
TL;DR: A simplified model of the human gut microbiota illustrates niche specialization and functional redundancy within members of its major bacterial phyla, and the importance of host glycans as a nutrient foundation that ensures ecosystem stability.
Evolution of symbiotic bacteria in the distal human intestine.
Jian Xu,Michael A. Mahowald,Ruth E. Ley,Catherine A. Lozupone,Micah Hamady,Eric C. Martens,Bernard Henrissat,Bernard Henrissat,Pedro M. Coutinho,Pedro M. Coutinho,Patrick Minx,P. Latreille,Holland S. Cordum,Andrew Van Brunt,Kyung-Ae Kim,Robert S. Fulton,Lucinda Fulton,Sandra W. Clifton,Richard K. Wilson,Robin D. Knight,Jeffrey I. Gordon +20 more
TL;DR: In this article, the authors examined how the intestinal environment affects microbial genome evolution and found that lateral gene transfer, mobile elements, and gene amplification have played important roles in affecting the ability of gut-dwelling Bacteroidetes to vary their cell surface, sense their environment, and harvest nutrient resources present in the distal intestine.