Michael A. Lutz
Johns Hopkins University School of Medicine
7 Papers
3 Citations
Michael A. Lutz is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: T cell & Biology. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Michael A. Lutz include Johns Hopkins University.
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Papers
Hyaluronan Fragments Act as an Endogenous Danger Signal by Engaging TLR2
Kara A. Scheibner,Michael A. Lutz,Sada Boodoo,Matthew J. Fenton,Jonathan D. Powell,Maureen R. Horton +5 more
TL;DR: It is demonstrated that LMW HA activates the innate immune response via TLR-2 in a MyD88-, IL-1R-associated kinase-, TNFR-associated factor-6-, protein kinase Cζ-, and NF-κB-dependent pathway and can act as an adjuvant promoting Ag-specific T cell responses in vivo in wild-type mice.
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A role for mammalian target of rapamycin in regulating T cell activation versus anergy.
Yan Zheng,Samuel L. Collins,Michael A. Lutz,Amy Allen,Thomas P. Kole,Paul E. Zarek,Jonathan D. Powell +6 more
TL;DR: The data suggest that by integrating environmental cues, mTOR plays a central role in determining the outcome of Ag recognition, and that T cells engineered to express a rapamycin-resistant mTOR construct are resistant to anergy induction caused byRapamycin.
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Guo N. Huang,David L. Huso,Samuel Bouyain,Jianchen Tu,Kelly A. McCorkell,Michael J. May,Yuwen Zhu,Michael A. Lutz,Samuel L. Collins,Marlin H. Dehoff,Shin Kang,Katharine A. Whartenby,Jonathan D. Powell,Daniel J. Leahy,Paul F. Worley +14 more
TL;DR: It is found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation, achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin.
Erratum: Egr-2 and Egr-3 are negative regulators of T cell activation (Nature Immunology (2005) 6 (472-480))
Meredith G. Safford,Samuel L. Collins,Michael A. Lutz,Amy Allen,Ching Tai Huang,Jeanne Kowalski,Amanda L. Blackford,Maureen R. Horton,Charles G. Drake,Ronald H. Schwartz,Jonathan D. Powell +10 more
TL;DR: On page 476, the top panel of Figure 5c was incorrect, the correct figure is provided here.
Egr-2 and Egr-3 are negative regulators of T cell activation.
Meredith G. Safford,Samuel L. Collins,Michael A. Lutz,Amy Allen,Ching Tai Huang,Jeanne Kowalski,Amanda L. Blackford,Maureen R. Horton,Charles G. Drake,Ronald H. Schwartz,Jonathan D. Powell +10 more
TL;DR: Overexpression of Egr2 and Egr3 was associated with an increase in the E3 ubiquitin ligase Cbl-b and inhibition of T cell activation, and data support the idea that Egr-2 andEgr-3 are involved in promoting a T cell receptor–induced negative regulatory genetic program.