Miaoxin Lin
Nanjing University
7 Papers
197 Citations
Miaoxin Lin is an academic researcher from Nanjing University. The author has contributed to research in topics: DNA & Ascorbic acid. The author has an hindex of 7, co-authored 7 publications.
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Papers
Promotive effect of the platinum moiety on the DNA cleavage activity of copper-based artificial nucleases.
TL;DR: Results show that the presence of a platinum(II) center in copper( II) complexes strengthens both their DNA binding ability and DNA cleavage efficiency.
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Platinum(II) compounds bearing bone-targeting group: synthesis, crystal structure and antitumor activity
TL;DR: Platinum(II) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma and ovarian cancer cell lines with different apoptotic pathways from that of cisplatin.
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Reversible DNA Condensation Induced by a Tetranuclear Nickel(II) Complex
Xindian Dong,Xiaoyong Wang,Yafeng He,Zhen Yu,Miaoxin Lin,Changli Zhang,Jing Wang,Yajie Song,Yangmiao Zhang,Zhipeng Liu,Yi-Zhi Li,Zijian Guo +11 more
TL;DR: The tetranuclear nickel(II) complex synthesized as a nonviral vector to induce DNA condensation satisfies the requirements of a gene vector in all of these respects and has been achieved using the chelator ethylenediaminetetraacetic acid for the first time.
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DNA Cross‐Linking Patterns Induced by an Antitumor‐Active Trinuclear Platinum Complex and Comparison with Its Dinuclear Analogue
Jianhui Zhu,Yongmei Zhao,Yanyan Zhu,Ziyi Wu,Miaoxin Lin,Weijiang He,Yan Wang,Guangju Chen,Lei Dong,Junfeng Zhang,Yi Lu,Zijian Guo +11 more
TL;DR: The remarkable differences between 1 and 2 in DNA binding and cross-linking provide mechanistic insights into their different cytotoxicity against the tumor cell lines; these insights are useful for designing future antitumor agents.
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Cellular and biomolecular responses of human ovarian cancer cells to cytostatic dinuclear platinum(II) complexes
TL;DR: It is demonstrated that dinuclear platinum(II) complexes can induce some cellular responses different from those caused by cisplatin, and activation of phospho-ERK1/2 andospho-p38 MAPK by these complexes is closely related to the cytostatic activity.
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