Miao Li
Indiana University
6 Papers
1 Citations
Miao Li is an academic researcher from Indiana University. The author has contributed to research in topics: Receptor & Chemistry. The author has an hindex of 2, co-authored 3 publications.
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Papers
Tracking Single Molecules in Biomembranes: Is Seeing Always Believing?
TL;DR: The application of SPT to understanding the nanoscale heterogeneities of plasma membranes is reviewed, with a focus on the unique challenges, pitfalls, and limitations that confront the use of nanoparticles as imaging probes for tracking the dynamics of single molecules in cell membranes.
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Macrophage activation on "phagocytic synapse" arrays: Spacing of nanoclustered ligands directs TLR1/2 signaling with an intrinsic limit.
TL;DR: This study demonstrates the feasibility of using spatially patterned ligands to modulate innate immunity by showing that the receptor clusters of TLR1/2 act as a driver in integrating the spatial cues of ligands into cell-level activation events.
19
Construction of a Dengue NanoLuc Reporter Virus for In Vivo Live Imaging in Mice
Enyue Fang,Xiaohui Liu,Miao Li,Jingjing Liu,Zelun Zhang,Xinyu Liu,Xingxing Li,Wenjuan Li,Qinhua Peng,Yongxin Yu,Yuhua Li +10 more
TL;DR: A reporter DENV containing the NanoLuc reporter gene was constructed, which was inserted into the 5′ untranslated region and capsid junction region, enabling rapid virus rescue by in vitro ligation and found that the reporter virus maintained the neurovirulence of prototype DENV before engineering.
6
Immobile Ligands Enhance FcγR-TLR2/1 Crosstalk by Promoting Interface Overlap of Receptor Clusters.
TL;DR: In this article , the inflammatory response of macrophages from FcγR-TLR2/1 crosstalk inversely depends on the ligand mobility within a model pathogen membrane.
Spatial organization of FcγR and TLR2/1 on phagosome membranes differentially regulates their synergistic and inhibitory receptor crosstalk.
TL;DR: In this paper, a geometric manipulation strategy was used to physically alter the spatial distribution of FcγR and TLR2 on single phagosomes, and it was shown that the signaling synergy between the two receptors depends on the proximity of the receptors and decreases as spatial separation between them increases.