Mi-Yeon Kim
Medical Research Council
26 Papers
203 Citations
Mi-Yeon Kim is an academic researcher from Medical Research Council. The author has contributed to research in topics: T cell & CD40. The author has an hindex of 12, co-authored 16 publications. Previous affiliations of Mi-Yeon Kim include University of Birmingham.
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Papers
Mice Deficient in OX40 and CD30 Signals Lack Memory Antibody Responses because of Deficient CD4 T Cell Memory
Fabrina Gaspal,Mi-Yeon Kim,Fiona M. McConnell,Chandra Raykundalia,Vasilios Bekiaris,Peter J. L. Lane +5 more
TL;DR: It is shown that OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4+CD3− cells in vitro.
OX40 Ligand and CD30 Ligand Are Expressed on Adult but Not Neonatal CD4+CD3− Inducer Cells: Evidence That IL-7 Signals Regulate CD30 Ligand but Not OX40 Ligand Expression
Mi-Yeon Kim,Graham Anderson,Andrea J. White,Eric J. Jenkinson,Wiebke Arlt,Inga-Lill Mårtensson,Lena Erlandsson,Peter J. L. Lane +7 more
TL;DR: It was found that IL-7 signaling through the common cytokine receptor γ-chain was critical for the optimal expression of both TNF-related activation-induced cytokine and CD30L but not OX40L, which helps to explain why exposure to Ag in neonatal life induces tolerance rather than immunity.
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Neonatal and adult CD4+ CD3- cells share similar gene expression profile, and neonatal cells up-regulate OX40 ligand in response to TL1A (TNFSF15).
Mi-Yeon Kim,Kai-Michael Toellner,Andrea J. White,Fiona M. McConnell,Fabrina Gaspal,Sonia M. Parnell,Eric J. Jenkinson,Graham Anderson,Peter J. L. Lane +8 more
TL;DR: The quantitative expression of a set of immunity-related genes, including TNF family members, chemokine receptors, and transcription factors, in a CD4+CD3− accessory cell is reported, and it is demonstrated that this differentiation occurs in vivo: neonatal CD4- CD3− cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient.
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Function of CD4+CD3- cells in relation to B- and T-zone stroma in spleen.
Mi-Yeon Kim,Fiona M. McConnell,Fabrina Gaspal,Andrea J. White,Stephanie H. Glanville,Vasilios Bekiaris,Lucy S. K. Walker,Jorge Caamano,Eric J. Jenkinson,Graham Anderson,Peter J. L. Lane +10 more
TL;DR: It is proposed that the function of CD4+CD3- cells is to form a link between primed CD4 T cells and the underlying stromal elements, creating distinct microenvironments in which they enable effector responses.
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Two sides of a cellular coin: CD4+CD3− cells regulate memory responses and lymph-node organization
TL;DR: It is proposed that CD4+CD3− cells have two functions: a well-established role in organizing lymphoid tissue during development, and a newly discovered role in supporting T-cell help for B cells both during affinity maturation in germinal centres and for memory antibody responses.
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