Merve Avar
University of Zurich
14 Papers
74 Citations
Merve Avar is an academic researcher from University of Zurich. The author has contributed to research in topics: Gene & RNA interference. The author has an hindex of 4, co-authored 13 publications.
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Papers
Genome-wide transcriptomics identifies an early preclinical signature of prion infection.
Silvia Sorce,Mario Nuvolone,Mario Nuvolone,Giancarlo Russo,Andra Chincisan,Daniel Heinzer,Merve Avar,Manuela Pfammatter,Petra Schwarz,Mirzet Delic,Micha Müller,Simone Hornemann,Despina Sanoudou,Claudia Scheckel,Adriano Aguzzi +14 more
TL;DR: A searchable genome-wide atlas of mRNA abundance and splicing alterations during the course of disease in prion-inoculated mice suggests that glial pathophysiology, rather than neuronal demise, could be the final driver of disease.
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
Marc Emmenegger,Elena De Cecco,Marian Hruska-Plochan,Timo Eninger,Timo Eninger,Matthias Schneider,Melanie Barth,Melanie Barth,Elena Tantardini,Pierre De Rossi,Mehtap Bacioglu,Mehtap Bacioglu,Rebekah G. Langston,Alice Kaganovich,Nora Bengoa-Vergniory,Andrés González-Guerra,Merve Avar,Daniel Heinzer,Regina Reimann,Lisa M. Häsler,Lisa M. Häsler,Therese W. Herling,Naunehal S. Matharu,Natalie Landeck,Kelvin C. Luk,Ronald Melki,Philipp J. Kahle,Philipp J. Kahle,Simone Hornemann,Tuomas P. J. Knowles,Mark R. Cookson,Magdalini Polymenidou,Mathias Jucker,Mathias Jucker,Adriano Aguzzi +34 more
TL;DR: In this article, the expression pattern of LAG3 in human and mouse brains was analyzed, and it was shown that LAG-3 interacts with α-synuclein fibrils, but the specificity of this interaction appears limited.
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
Georg Meisl,Timothy D. Kurt,Itzel Condado-Morales,Itzel Condado-Morales,Cyrus Bett,Silvia Sorce,Mario Nuvolone,Mario Nuvolone,Thomas C. T. Michaels,Thomas C. T. Michaels,Daniel Heinzer,Merve Avar,Samuel I. A. Cohen,Simone Hornemann,Adriano Aguzzi,Christopher M. Dobson,Christina J. Sigurdson,Tuomas P. J. Knowles +17 more
TL;DR: In this paper, a mathematical framework with kinetics of the accumulation of prions in mice and microfluidic measurements of aggregate size was brought together to dissect the overall aggregation reaction into its constituent processes and quantify the reaction rates in mice.
Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.
Annika Keller,Mario Nuvolone,Mario Nuvolone,Irina Abakumova,Andra Chincisan,Regina Reimann,Merve Avar,Daniel Heinzer,Simone Hornemann,Josephin Wagner,Daniel Kirschenbaum,Fabian F. Voigt,Caihong Zhu,Luca Regli,Fritjof Helmchen,Adriano Aguzzi +15 more
TL;DR: It is found that Pdgfbret/ret mice have a similar prion disease incubation time as their littermate controls regardless of the route of prion transmission, indicating that BBB permeability is irrelevant to the initiation of prions disease, even when prions are administered parenterally.
An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein.
Eleanna Kara,Eleanna Kara,Alessandro Crimi,Anne Wiedmer,Marc Emmenegger,Claudia Manzoni,Claudia Manzoni,Sara Bandres-Ciga,Karishma D’Sa,Karishma D’Sa,Karishma D’Sa,Regina H. Reynolds,Regina H. Reynolds,Juan A. Botía,Juan A. Botía,Marco Losa,Veronika Lysenko,Manfredi Carta,Daniel Heinzer,Merve Avar,Andra Chincisan,Cornelis Blauwendraat,Sonia García-Ruiz,Sonia García-Ruiz,Daniel Patrick Pease,Lorene Mottier,Alessandra Carrella,Dezirae Beck-Schneider,Andreia D. Magalhães,Caroline Aemisegger,Alexandre Theocharides,Zhanyun Fan,Jordan D. Marks,Jordan D. Marks,Sarah C. Hopp,Andrey Y. Abramov,Patrick A. Lewis,Patrick A. Lewis,Patrick A. Lewis,Mina Ryten,Mina Ryten,John Hardy,Bradley T. Hyman,Adriano Aguzzi +43 more
TL;DR: Weighted gene co-expression network analysis and weighted protein-protein network interaction analysis show that those hits cluster in networks that include known PD genes more frequently than expected by random chance.
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