Merryn Brettle
University of New South Wales
13 Papers
58 Citations
Merryn Brettle is an academic researcher from University of New South Wales. The author has contributed to research in topics: Actin cytoskeleton & Neurite. The author has an hindex of 6, co-authored 10 publications.
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Papers
Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells.
Nikki M. Curthoys,Hannah Freittag,Andrea Connor,Melissa Desouza,Merryn Brettle,Anne Poljak,Amelia Hall,Edna C. Hardeman,Galina Schevzov,Peter W. Gunning,Thomas Fath +10 more
TL;DR: Revealing the molecular machinery that regulates the actin cytoskeleton during neurite outgrowth may provide new therapeutic strategies to promote neurite regeneration after nerve injury and highlight the functional diversity of different tropomyosin isoforms during neuritogenesis.
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Soluble LILRA3 promotes neurite outgrowth and synapses formation through a high-affinity interaction with Nogo 66
Hongyan An,Merryn Brettle,Terry Lee,Benjamin Heng,Chai K. Lim,Gilles J. Guillemin,Megan S. Lord,Enrico Klotzsch,Carolyn L. Geczy,Katherine Bryant,Thomas Fath,Nicodemus Tedla +11 more
TL;DR: LILRA3 protein is a soluble new high-affinity ligand to Nogo 66 and promotes neurite outgrowth and synapse formation in primary cortical neurons by antagonising Nogo-66-mediated inhibition.
26
Amyotrophic lateral sclerosis-associated mutant profilin 1 increases dendritic arborisation and spine formation in primary hippocampal neurons
TL;DR: It is shown that expression of the ALS-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons.
16
Copper chelation suppresses epithelial-mesenchymal transition by inhibition of canonical and non-canonical TGF-β signaling pathways in cancer
Ensieh M. Poursani,Daniele Mercatelli,Prahlad V. Raninga,Jessica L. Bell,Federica Saletta,F. Kohane,Daniel P. Neumann,Jourdin R. C. Rouaen,Toni Rose Jue,Filip Michniewicz,E. Kasiou,Maria Tsoli,Giuseppe Cirillo,Shafagh A. Waters,T. Shai-Hee,Merryn Brettle,Iveta Slapetova,Maria Kasherman,Renee Whan,Fernando Souza-Fonseca-Guimaraes,Linda T. Vahdat,David S. Ziegler,John G. Lock,Federico M. Giorgi,Kum Kum Khanna,Orazio Vittorio +25 more
TL;DR: The study suggests that copper chelation therapy represents a potentially effective therapeutic approach for targeting TGF-β and inhibiting EMT in a diverse range of cancers.
11
Functional characterisation of filamentous actin probe expression in neuronal cells.
Shrujna Patel,Sandra Fok,Holly Stefen,Tamara Tomanic,Esmeralda Paric,Rosanna Herold,Merryn Brettle,Aleksandra Djordjevic,Thomas Fath +8 more
TL;DR: The results of this study demonstrate the effects that filamentous actin tracking probes can have on the axonal and dendritic compartments of neuronal cells and emphasise the care that must be taken when interpreting data from experiments using these probes.