Mengru Wang
Zhengzhou University
13 Papers
16 Citations
Mengru Wang is an academic researcher from Zhengzhou University. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Matrine. The author has an hindex of 3, co-authored 8 publications.
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Papers
Modulation of the HMGB1/TLR4/NF-κB signaling pathway in the CNS by matrine in experimental autoimmune encephalomyelitis.
Yaojuan Chu,Yilei Jing,Xiaoyu Zhao,Mengru Wang,Mingliang Zhang,Rui Ma,Wendi Ma,Ying Lv,Lin Zhu +8 more
TL;DR: In this paper, the authors showed that MAT treatment alleviated disease severity of ongoing EAE, reduced inflammatory infiltration and demyelination, and reduced the production of inflammatory factors including TNF-α, IL-6, and IL-1β in the CNS.
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Matrine Inhibits CNS Autoimmunity Through an IFN-β-Dependent Mechanism.
Yaojuan Chu,Wendi Ma,Rodolfo Thomé,Jie Dan Ping,Fang-Zhou Liu,Mengru Wang,Mingliang Zhang,Guang-Xian Zhang,Lin Zhu +8 more
TL;DR: This study demonstrates that MAT exerts its therapeutic effect in EAE through an IFN-β/IL-27/ IL-10 pathway, and is likely a novel, safe, low-cost, and effective therapy as an alternative to exogenous IFn-β for MS.
Matrine treatment induced an A2 astrocyte phenotype and protected the blood-brain barrier in CNS autoimmunity.
TL;DR: This paper showed that MAT treatment inhibited the generation of neurotoxic A1 astrocytes and promoted neuroprotective A2 astroccytes in the CNS of EAE, most likely by inhibiting production of the A1inducing cytokine cocktail.
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Choroid plexus-selective inactivation of adenosine A2A receptors protects against T cell infiltration and experimental autoimmune encephalomyelitis
Wu Zheng,Yijia Feng,Zhenhai Zeng,Mengqian Ye,Mengru Wang,Xin Liu,Ping Tang,Hui-fang Shang,Xiao-Wei Sun,Xiangxiang Lin,Muran Wang,Zhengzheng Li,Yiyun Weng,Wei Guo,Serhii Vakal,Jiang-Fan Chen +15 more
TL;DR: In this article , the choroid plexus (CP) was found to be a key site for the first wave of immune cell infiltration in experimental autoimmune encephalomyelitis (EAE), for the control of immune cells trafficking.
Matrine alleviates astrogliosis through sphingosine 1-phosphate signaling in experimental autoimmune encephalomyelitis.
TL;DR: It is demonstrated that matrine alleviated astrogliosis in the CNS of EAE rats, and downregulated levels of SPH, S1P and S1p1 expression in CNS tissues and astrocytes, indicating that MAT could alleviate astrogLiosis in EAE through diminishing the SPH/SPHK/S1P1 pathway.
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