Menglin Li
Peking Union Medical College
31 Papers
33 Citations
Menglin Li is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Proteome. The author has an hindex of 11, co-authored 28 publications.
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Papers
A comprehensive analysis and annotation of human normal urinary proteome.
Mindi Zhao,Menglin Li,Yehong Yang,Zhengguang Guo,Ying Sun,Chen Shao,Mingxi Li,Wei Sun,Youhe Gao +8 more
TL;DR: In this paper, an in-depth analysis of the urinary proteome is presented based on different separation strategies, including direct one dimensional liquid chromatography–tandem mass spectrometry (LC/MS/MS), two dimensional LC/ MS/MS, and gel-eluted liquid fraction entrapment electrophoresis/liquid-phase isoelectric focusing followed by two dimensional Liquid Chromatography-MS-MS.
Changes of proteins induced by anticoagulants can be more sensitively detected in urine than in plasma.
Menglin Li,Mindi Zhao,Youhe Gao +2 more
TL;DR: It is hypothesized that change of blood can be reflected in urine more sensitively than plasma, and the interference into the blood by two anticoagulants heparin or argatroban is introduced, indicating that urine may serve as a source for more sensitive detection of protein biomarkers than plasma.
Dynamic changes of urinary proteins in a focal segmental glomerulosclerosis rat model
TL;DR: A rat model of adriamycin-induced nephropathy resembling human focal segmental glomerulosclerosis (FSGS) development is used to identify proteins changed in different stages of FSGS in rat models, which may aid in biomarker development and the understanding ofFSGS pathogenesis.
4,5 caffeoylquinic acid and scutellarin, identified by integrated metabolomics and proteomics approach as the active ingredients of Dengzhan Shengmai, act against chronic cerebral hypoperfusion by regulating glutamatergic and GABAergic synapses.
TL;DR: Investigation of the active substances and mechanism of Dengzhan Shengmai against CCH proved DZSM and its active ingredients had the effect of regulating glutamatergic and GABAergic synapses.
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Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry
TL;DR: The combination of LC×LC and MHC system provides a powerful technique for global chemical profiling of DZSM and provided feasible strategy for other complex systems.
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