Menglan Chen
University of Minnesota
36 Papers
384 Citations
Menglan Chen is an academic researcher from University of Minnesota. The author has contributed to research in topics: Medicine & Mercapturic acid. The author has an hindex of 22, co-authored 32 publications.
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Papers
•Journal Article
Quantitation of Urinary Metabolites of a Tobacco-specific Lung Carcinogen after Smoking Cessation
Stephen S. Hecht,Steven G. Carmella,Menglan Chen,J. F. Dor Koch,Andrew T. Miller,Sharon E. Murphy,Joni Jensen,Cheryl L. Zimmerman,Dorothy K. Hatsukami +8 more
TL;DR: It is demonstrated that NNAL and NNal-Gluc are slowly cleared from the body after smoking cessation, indicating the presence of a high-affinity compartment where NNK, NNAl, and/or NNNAL- Gluc are retained or sequestered and slowly released.
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Effects of Smoking Cessation on Eight Urinary Tobacco Carcinogen and Toxicant Biomarkers
Steven G. Carmella,Menglan Chen,Shaomei Han,Anna Briggs,Joni Jensen,Dorothy K. Hatsukami,Stephen S. Hecht +6 more
TL;DR: In this paper, the persistence at various times (3, 7, 14, 21, 28, 42, and 56 days) of eight tobacco smoke carcinogen and toxicant biomarkers in the urine of 17 smokers who stopped smoking was determined.
Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial
Dorothy K. Hatsukami,Xianghua Luo,Joni Jensen,Mustafa al'Absi,Sharon S Allen,Steven G. Carmella,Menglan Chen,Paul M. Cinciripini,Rachel L Denlinger-Apte,David J. Drobes,Joseph S. Koopmeiners,Tonya Lane,Chap T. Le,Scott J. Leischow,Kai Luo,F. Joseph McClernon,Sharon E. Murphy,Viviana Paiano,Jason D. Robinson,Herbert H. Severson,Christopher J. Sipe,Andrew A. Strasser,Lori S Strayer,Mei Kuen Tang,Ryan Vandrey,Stephen S. Hecht,Neal L. Benowitz,Eric C. Donny +27 more
TL;DR: Among smokers, immediate reduction of nicotine in cigarettes led to significantly greater decreases in biomarkers of smoke exposure across time compared with gradual reduction or a control group, with no significant differences between gradual reduction and control.
•Journal Article
Abstract #3014: Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers
Steven G. Carmella,Menglan Chen,Shaomei Han,Joni Jensen,Anna Briggs,Dorothy K. Hatsukami,Stephen S. Hecht +6 more
TL;DR: The results of this study demonstrate that the tobacco smoke carcinogen/toxicant biomarkers MHBMA, HPMA, HBMA, SPMA, HEMA, 1-HOP, and NNAL are related to smoking and are good indicators of the impact of smoking on human exposure to 1,3-butadiene, acrolein, crotonaldehyde, benzene, ethylene oxide, polycyclic aromatic hydrocarbons (PAH), and NNK.
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Metabolites of a tobacco-specific carcinogen in urine from newborns.
TL;DR: Two metabolites of the tobacco-specific transplacental carcinogen NNK can be detected in the urine from newborns of mothers who smoked cigarettes during pregnancy.
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