Menghang Xia
National Institutes of Health
239 Papers
1K Citations
Menghang Xia is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Biology & Chemistry. The author has an hindex of 48, co-authored 193 publications. Previous affiliations of Menghang Xia include Research Triangle Park & University of California, San Francisco.
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Papers
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
Miao Xu,Emily M. Lee,Zhexing Wen,Yichen Cheng,Wei Kai Huang,Xuyu Qian,Julia Tcw,Jennifer Kouznetsova,Sarah C. Ogden,Christy Hammack,Fadi Jacob,Ha Nam Nguyen,Misha Itkin,Catherine Hanna,Paul Shinn,Chase Allen,Samuel G. Michael,Anton Simeonov,Wenwei Huang,Kimberly M. Christian,Alison Goate,Kristen J. Brennand,Ruili Huang,Menghang Xia,Guo Li Ming,Wei Zheng,Hongjun Song,Hengli Tang +27 more
TL;DR: A pan-caspase inhibitor, emricasan, inhibited ZIKV-induced increases in caspase-3 activity and protected human cortical neural progenitors in both monolayer and three-dimensional organoid cultures, and combination treatments using one compound from each category (neuroprotective and antiviral) further increased protection of human neural progensitors and astrocytes from ZIKv-induced cell death.
High-throughput screening assays for the identification of chemical probes
James Inglese,Ronald L. Johnson,Anton Simeonov,Menghang Xia,Wei Zheng,Christopher P. Austin,Douglas S. Auld +6 more
TL;DR: High-throughput screening (HTS) assays enable the testing of large numbers of chemical substances for activity in diverse areas of biology as mentioned in this paper, including signal transduction pathways and complex networks functioning in cellular environments.
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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Anju Singh,Sreedhar Venkannagari,Kyu H. Oh,Ya Qin Zhang,Jason M. Rohde,Li Liu,Sridhar Nimmagadda,Kuladeep Sudini,Kyle R. Brimacombe,Sachin Gajghate,Jinfang Ma,Amy Wang,Xin Xu,Sampada A. Shahane,Menghang Xia,Juhyung Woo,George A. Mensah,Zhibin Wang,Marc Ferrer,Edward Gabrielson,Zhuyin Li,Fraydoon Rastinejad,Min Shen,Matthew B. Boxer,Shyam Biswal +24 more
TL;DR: It is concluded that targeting NRF2 may represent a promising strategy for the treatment of advanced NSCLC because of its high specificity and selectivity and its ability to bind to and inhibit its downstream target gene expression.
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: The challenge ahead
William H. Goodson,Leroy Lowe,David O. Carpenter,Michael Gilbertson,Abdul Manaf Ali,Adela Lopez de Cerain Salsamendi,Ahmed Lasfar,Amancio Carnero,Amaya Azqueta,Amedeo Amedei,Amelia K Charles,Andrew Collins,Andrew Ward,Anna C. Salzberg,Annamaria Colacci,Ann-Karin Olsen,Arthur Berg,Barry J. Barclay,Binhua P. Zhou,Carmen Blanco-Aparicio,Carolyn J. Baglole,Chenfang Dong,Chiara Mondello,Chia-Wen Hsu,Christian C. Naus,Clement G. Yedjou,Colleen S. Curran,Dale W. Laird,Daniel C. Koch,Danielle J Carlin,Dean W. Felsher,Debasish Roy,Dustin G. Brown,Edward A. Ratovitski,Elizabeth P. Ryan,Emanuela Corsini,Emilio Rojas,Eun-Yi Moon,Ezio Laconi,Fabio Marongiu,Fahd Al-Mulla,Ferdinando Chiaradonna,Firouz Darroudi,Francis Martin,Frederik J. van Schooten,Gary S. Goldberg,Gerard Wagemaker,Gladys N. Nangami,Gloria M. Calaf,Gloria M. Calaf,Graeme Williams,Gregory T. Wolf,Gudrun Koppen,Gunnar Brunborg,H. Kim Lyerly,Harini Krishnan,Hasiah Ab Hamid,Hemad Yasaei,Hideko Sone,Hiroshi Kondoh,Hosni Salem,Hsue-Yin Hsu,Hyun Ho Park,Igor Koturbash,Isabelle R. Miousse,A. Ivana Scovassi,James E. Klaunig,Jan Vondráček,Jayadev Raju,Jesse Roman,Jesse Roman,John Pierce Wise,Jonathan Whitfield,Jordan Woodrick,Joseph Christopher,Josiah Ochieng,Juan Fernando Martinez-Leal,Judith Weisz,Julia Kravchenko,Jun Sun,Kalan R. Prudhomme,Kannan Badri Narayanan,Karine A. Cohen-Solal,Kim Moorwood,Laetitia Gonzalez,Laura Soucek,Le Jian,Leandro S. D'Abronzo,Liang Tzung Lin,Lin Li,Linda S M Gulliver,Lisa J. McCawley,Lorenzo Memeo,Louis Vermeulen,Luc Leyns,Luoping Zhang,Mahara Valverde,Mahin Khatami,Maria Romano,Marion Chapellier,Marc A. Williams,Mark Wade,Masoud H. Manjili,Matilde E. Lleonart,Menghang Xia,Michael J. Gonzalez,Michalis V. Karamouzis,Micheline Kirsch-Volders,Monica Vaccari,Nancy B. Kuemmerle,Nancy B. Kuemmerle,Neetu Singh,Nichola Cruickshanks,Nicole Kleinstreuer,Nik van Larebeke,Nuzhat Ahmed,Olugbemiga Ogunkua,Periyadan K. Krishnakumar,Pankaj Vadgama,Paola A. Marignani,Paramita M. Ghosh,Patricia Ostrosky-Wegman,Patricia A. Thompson,Paul Dent,Petr Heneberg,Philippa D. Darbre,Po Sing Leung,Pratima Nangia-Makker,Qiang Shawn Cheng,R. Brooks Robey,R. Brooks Robey,Rabeah Al-Temaimi,Rabindra Roy,Rafaela Andrade-Vieira,Ranjeet Kumar Sinha,Rekha Mehta,Renza Vento,Renza Vento,Riccardo Di Fiore,Richard Ponce-Cusi,Rita Dornetshuber-Fleiss,Rita Dornetshuber-Fleiss,Rita Nahta,Robert C. Castellino,Roberta Palorini,Roslida Abd Hamid,Sabine A. S. Langie,Sakina E. Eltom,Samira A. Brooks,Sandra Ryeom,Sandra S. Wise,Sarah N Bay,Shelley A. Harris,Shelley A. Harris,Silvana Papagerakis,Simona Romano,Sofia Pavanello,Staffan Eriksson,Stefano Forte,Stephanie C. Casey,Sudjit Luanpitpong,Tae-Jin Lee,Takemi Otsuki,Tao Chen,Thierry Massfelder,Thomas Sanderson,Tiziana Guarnieri,Tove Hultman,Valérian Dormoy,Valérian Dormoy,Valerie Odero-Marah,Venkata S. Sabbisetti,Véronique Maguer-Satta,W. Kimryn Rathmell,Wilhelm Engström,William K. Decker,William H. Bisson,Yon Rojanasakul,Yunus A. Luqmani,Zhenbang Chen,Zhiwei Hu +180 more
TL;DR: Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer.
Integrated Model of Chemical Perturbations of a Biological Pathway Using 18 In Vitro High Throughput Screening Assays for the Estrogen Receptor
Richard S. Judson,F. M. G. Magpantay,Vijay Chickarmane,Cymra Haskell,Nessy Tania,Jean E. Taylor,Menghang Xia,Ruili Huang,Daniel M. Rotroff,Dayne L. Filer,Keith A. Houck,Matthew T. Martin,Nisha S. Sipes,Ann M. Richard,Kamel Mansouri,R. Woodrow Setzer,Thomas B. Knudsen,Kevin M. Crofton,Russell S. Thomas +18 more
TL;DR: A computational network model is demonstrated that integrates 18 in vitro, high-throughput screening assays measuring estrogen receptor (ER) binding, dimerization, chromatin binding, transcriptional activation, and ER-dependent cell proliferation and is generalizable to any molecular pathway for which there are multiple upstream and downstream assays available.
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