Mengdi Liu
Nanjing Medical University
6 Papers
5 Citations
Mengdi Liu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: MPTP & Dopaminergic. The author has an hindex of 5, co-authored 6 publications.
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Papers
Aquaporin-4 promotes memory consolidation in Morris water maze
TL;DR: Findings indicate that AQP4 plays a modulatory role in memory consolidation, and targeting glial aquaporin-4 may be a new therapeutic strategy for neurodegenerative disorders and related memory impairment.
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Enhanced MK-801-induced locomotion in Kir6.2 knockout mice.
TL;DR: K-ATP channels are involved in the regulation of MK-801-induced acute symptoms of schizophrenia, which is associated with the neural excitability, and may provide valuable information for the development of new treatments for schizophrenia.
5
Patent
Application of dexrazoxane in preparation of drug for treating neurodegenerative diseases
Gang Hu,Ming Lu,Jian-Hua Ding,Cunjin Su,Yi Fan,Mengdi Liu,Fangfang Zhao,Ling Wang +7 more
- 15 Feb 2012
TL;DR: In this article, the authors provided application of dexrazoxane in preparation of drug for treating neurodegenerative diseases, and the results showed that dexrazoxide can be used as an active ingredient to prepare the drug.
Aquaporin-4 deficiency diminishes the differential degeneration of midbrain dopaminergic neurons in experimental Parkinson’s disease
TL;DR: Results demonstrate that glial AQP4 is involved in the susceptibility differences of DA neurons between SN and VTA, although the precise mechanism of AQP 4 remains to be explored.
Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson's disease.
Meng Mei,Yuanzhang Zhou,Mengdi Liu,Fangfang Zhao,Cong Wang,Jian-Hua Ding,Ming Lu,Gang Hu,Gang Hu +8 more
TL;DR: It is demonstrated for the first time that Dexrazoxane (Dex), a drug clinically used to reduce doxorubicin-induced cardiotoxicity in chemotherapy, can enter into midbrain and striatum through broken BBB in 6-hydroxydopamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced rodent models of PD.