17 Papers
2 Citations
Meng Xu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 4 publications.
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Papers
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell
Xinhai Zhu,Ke-Fang Li,Guichao Liu,Ruan Wu,Si-Yun Wang,Meng Xu,Ligong Lu,Peng Liu +7 more
TL;DR: The findings reveal that the metabolite butyrate of the gut microbiota facilitates the efficacy of anti-PD-1 immunotherapy by modulating TCR signaling of cytotoxic CD8 T cells, and is a highly promising therapeutic biomarker for enhancing antitumor immunity.
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Strategies for developing PD-1 inhibitors and future directions.
TL;DR: A review of PD-1/PD-L1 inhibitors can be found in this article , where the authors discuss the crystal structure of PD1 and L1/L1, and physiological and pathological roles played by PD1.
21
Cell Division Cycle-Associated Genes Are Potential Immune Regulators in Nasopharyngeal Carcinoma
TL;DR: CDCA gene family was upregulated in NPC, and their expressions were associated with adverse prognosis, and it was found that CDCA3/5/8 were involved in multiple immune-related pathways.
Two protein-coding genes act as a novel clinical signature to predict prognosis in patients with ovarian serous cystadenocarcinoma
TL;DR: The expression of the two genes in the two-gene model was associated with the prognostic outcomes of patients with ovarian serous cystadenocarcinoma; the model demonstrated potential as a novel prognostic indicator, which may have important clinical significance.
Expression of HIF-1α is a predictive marker of the efficacy of neoadjuvant chemotherapy for locally advanced cervical cancer.
Bin Yan,Quan‑Fu Ma,Wen‑Fu Tan,Hong‑Ning Cai,Yan‑Li Li,Zhi‑Gang Zhou,Xuan Dai,Fa‑Xia Zhu,Yu‑Jing Xiong,Meng Xu,Yu‑Lin Guo,Han Gao,Jun‑Bo Hu,Xu‑Feng Wu +13 more
TL;DR: The expression of HIF-1α may be able to predict the efficiency of NACT and may be considered an independent prognostic factor for stage IIB-IIIB cervical cancer.