Meng Li
Erasmus University Rotterdam
13 Papers
5 Citations
Meng Li is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Cancer & Liver cancer. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Meng Li include Erasmus University Medical Center & Guangzhou Institutes of Biomedicine and Health.
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Papers
Cancer-Associated Fibroblasts Provide a Stromal Niche for Liver Cancer Organoids That Confers Trophic Effects and Therapy Resistance
Jiaye Liu,Pengfei Li,Ling Wang,Meng Li,Zhouhong Ge,Lisanne Noordam,Ruby Lieshout,Monique M A Verstegen,Buyun Ma,Junhong Su,Qin Yang,Ruyi Zhang,Guoying Zhou,Lucia Campos Carrascosa,Dave Sprengers,Jan N. M. IJzermans,Ron Smits,Jaap Kwekkeboom,Luc J. W. van der Laan,Maikel P. Peppelenbosch,Qiuwei Pan,Wanlu Cao +21 more
TL;DR: 3D organotypic co-cultures of primary liver tumor–derived organoids with cancer-associated fibroblasts are established and robust effects of CAFs are shown in liver cancer nurturing and treatment resistance.
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Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth
Meng Li,Ling Wang,Yijin Wang,Shaoshi Zhang,Guoying Zhou,Ruby Lieshout,Buyun Ma,Jiaye Liu,Changbo Qu,Monique M A Verstegen,Dave Sprengers,Jaap Kwekkeboom,Luc J. W. van der Laan,Wanlu Cao,Maikel P. Peppelenbosch,Qiuwei Pan +15 more
TL;DR: Investigation of the mitochondrial morphodynamics and its functional consequences in human liver cancer finds increased mitochondrial fusion in liver cancer alters metabolism and fuels tumor cell growth.
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Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors.
Wanlu Cao,Jiaye Liu,Ling Wang,Meng Li,Monique M A Verstegen,Yuebang Yin,Buyun Ma,Kan Chen,Michiel Bolkestein,Dave Sprengers,Luc J. W. van der Laan,Michael Doukas,Jaap Kwekkeboom,Ron Smits,Maikel P. Peppelenbosch,Qiuwei Pan +15 more
TL;DR: Interestingly, single cells from the tumor organoids have high efficiency of organoid initiation, and a single organoid derived from a cancer cell is able to initiate a tumor in mice, indicating the enrichment of tumor-initiating cells in the tumororganoids.
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Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.
J. Jasper Deuring,Meng Li,Wanlu Cao,Sunrui Chen,Wenshi Wang,Colin de Haar,C. Janneke van der Woude,Maikel P. Peppelenbosch +7 more
TL;DR: The data indicate that the PXR is a major and clinically relevant antagonist of NF-κB activity in the intestinal epithelial compartment during inflammatory bowel disease.
Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target
Changbo Qu,Shaoshi Zhang,Wenshi Wang,Meng Li,Yijin Wang,Marieke van der Heijde-Mulder,Ehsan Shokrollahi,Mohamad S. Hakim,Mohamad S. Hakim,Nicolaas J. H. Raat,Maikel P. Peppelenbosch,Qiuwei Pan +11 more
TL;DR: Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target and mitochondrial permeability transition pore (MPTP), a newly identified component of ETC, provides basal defense against HEV infection.
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