Meng-Jung Chiang
Center for Biologics Evaluation and Research
6 Papers
11 Citations
Meng-Jung Chiang is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Hemagglutination assay & Vaccination. The author has an hindex of 6, co-authored 6 publications.
Chat about Author
Papers
H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps
Hang Xie,Xiu-Feng Wan,Zhiping Ye,Ewan P. Plant,Yangqing Zhao,Yifei Xu,Xing Li,Courtney Finch,Nan Zhao,Toshiaki Kawano,Olga Zoueva,Meng-Jung Chiang,Xianghong Jing,Zhengshi Lin,Anding Zhang,Yanhong Zhu +15 more
TL;DR: Molecular modeling indicated that the mutations of epidemic H3 strains were mainly located in antibody-binding sites A and B as compared with TX/12e, and human serologic testing on vaccination-induced cross-reactivity need be emphasized along with virus antigenic characterization by ferret model.
A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells.
Feng Wen,Lei Li,Nan Zhao,Meng-Jung Chiang,Hang Xie,Jim Cooley,Richard J. Webby,Peng George Wang,Xiu-Feng Wan +8 more
TL;DR: This study identified a molecular signature, Y161F, in hemagglutinin (HA) that resulted in increased virus growth in Madin-Darby canine kidney and Vero cells, two cell lines commonly used for influenza vaccine manufacturing, and suggests that a vaccine strain bearing the Y161f mutation in HA could potentially increase vaccine yields in mammalian cell culture systems.
27
Different Repeat Annual Influenza Vaccinations Improve the Antibody Response to Drifted Influenza Strains
Ewan P. Plant,Lucy J. Fredell,Blake A. Hatcher,Xing Li,Meng-Jung Chiang,Martina Kosikova,Hang Xie,Olga Zoueva,Angelia A. Cost,Zhiping Ye,Michael J Cooper +10 more
TL;DR: Changing the vaccine formulation results in an antibody repertoire that is better able to react with strains emerging after the vaccine virus strains are selected, and this effect is observed for both influenza A and B strains in groups of subjects vaccinated in three different seasons.
24
Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Meng-Jung Chiang,Faik N. Musayev,Martina Kosikova,Zhengshi Lin,Yamei Gao,Philip D. Mosier,Bashayer Althufairi,Zhiping Ye,Qibing Zhou,Umesh R. Desai,Hang Xie,Martin K. Safo +11 more
TL;DR: The results suggest that maintaining M1 pH-dependent conformational flexibility is critical for efficient virus replication, and position 88 is a key residue controlling M 1 pH- dependent conformational changes.
12
Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1
Philip D. Mosier,Meng-Jung Chiang,Zhengshi Lin,Yamei Gao,Bashayer Althufairi,Qibing Zhou,Qibing Zhou,Faik N. Musayev,Martin K. Safo,Hang Xie,Umesh R. Desai +10 more
TL;DR: It is demonstrated that M1 is a promising druggable target for the discovery of a completely new line of broad spectrum anti-IAV agents because the best molecule bound the M1 protein potently and weakened M1-M1 self-association.