Meng Jiang
Chinese Ministry of Education
6 Papers
11 Citations
Meng Jiang is an academic researcher from Chinese Ministry of Education. The author has contributed to research in topics: Systems pharmacology & Cancer. The author has an hindex of 5, co-authored 6 publications. Previous affiliations of Meng Jiang include Northwest University (China).
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Papers
Systems pharmacology uncover the mechanism of anti-non-small cell lung cancer for Hedyotis diffusa Willd.
Xing Su,Yueping Li,Meng Jiang,Jinglin Zhu,Chunli Zheng,Xuetong Chen,Jun Zhou,Yan Li,Yan Li,Wei Xiao,Yonghua Wang,Yonghua Wang +11 more
TL;DR: Results show that HDW treatment of NSCLC may activate immunity, achieve anti-inflammatory, anti-proliferative and anti-migration therapeutic effects by regulating multiple pathways and provides a new idea for understanding the mechanism of TCM.
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Gating TrkB switch by methylglyoxal enables GLO1 as a target for depression
Ziyin Wu,Ziyin Wu,Yingxue Fu,Yinfeng Yang,Chao Huang,Chunli Zheng,Zihu Guo,Zihao Yang,Xuetong Chen,Jinglin Zhu,Jinghui Wang,Xiaogang Li,Liyang Chen,Weiwei Zhou,Yangyang Chen,J.G. Wang,Yang Yang,Meng Jiang,Su-Shing Chen,Aiping Lu,Jianlin Liu,Yan Li,Shiguo Sun,Zhenzhong Wang,Wei Xiao,Yonghua Wang +25 more
TL;DR: A novel therapeutic axis of methylglyoxal (MGO)/tropomyosin receptor kinase B (TrkB) for treating major depressive disorder is reported and principles for the rational design of new antidepressants targeting GLO1 are depicted.
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Methylglyoxal modification of TrkB promotes synaptic plasticity and enhances resilience to chronic stress
Ziyin Wu,Ziyin Wu,Yingxue Fu,Yinfeng Yang,Chao Huang,Chunli Zheng,Zihu Guo,Zihao Yang,Xuetong Chen,Jinglin Zhu,Jinghui Wang,Xiaogang Li,Liyang Chen,Weiwei Zhou,Yangyang Chen,J.G. Wang,Yang Yang,Meng Jiang,Su-Shing Chen,Aiping Lu,Jianlin Liu,Yan Li,Shiguo Sun,Zhenzhong Wang,Wei Xiao,Yonghua Wang +25 more
TL;DR: It is found that MGO concentrations are decreased in the prefrontal cortex and hippocampus in rats subjected to chronic stress, and low-dose MGO treatment remarkedly enhances resilience to stress and alleviates depression-like symptoms.
Synergistic Effect of Network-Based Multicomponent Drugs: An Investigation on the Treatment of Non-Small-Cell Lung Cancer with Compound Liuju Formula.
Xing Su,Meng Jiang,Yueping Li,Jinglin Zhu,Chunli Zheng,Xuetong Chen,Jun Zhou,Wei Xiao,Yonghua Wang,Yonghua Wang,Yan Li,Yan Li +11 more
TL;DR: The systems pharmacology method was applied in this study, which provides a new direction for analyzing the mechanism of TCM, and it was confirmed that the bioactive compounds of compound Liuju formula have not only a killing effect on NSCLC tumor cells but also a synergistic effect on inhibiting the secretion of correlative inflammatory mediators.
Systems pharmacology analysis of synergy of TCM: an example using saffron formula.
Jianling Liu,Jingjing Liu,Fengxia Shen,Zonghui Qin,Meng Jiang,Jinglin Zhu,Zhenzhong Wang,Jun Zhou,Yingxue Fu,Xuetong Chen,Chao Huang,Wei Xiao,Chunli Zheng,Yonghua Wang +13 more
TL;DR: A systems-based method is proposed and applied to three representative Chinese medicines in compound saffron formula (CSF) to elucidate why animal spices and herbs can have pharmacologically synergistic effects on CVDs, which provides a new way for drug discovery.