Melody E. Clark
University of California, San Diego
5 Papers
73 Citations
Melody E. Clark is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Enhancer & Gonadotropin-releasing hormone. The author has an hindex of 5, co-authored 5 publications.
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Papers
The Otx2 Homeoprotein Regulates Expression from the Gonadotropin- Releasing Hormone Proximal Promoter
TL;DR: Data suggest that Otx2 is important in the development of the GnRH neuron and/or in the maintenance of GnRH expression in the adult mouse hypothalamus, and a highly conserved bicoid-related Otx target sequence within the proximal promoter region of the gnRH gene from several species is identified.
TALE Homeodomain Proteins Regulate Gonadotropin-releasing Hormone Gene Expression Independently and via Interactions with Oct-1
Naama Rave-Harel,Marjory L. Givens,Shelley B. Nelson,Hao A. Duong,Djurdjica Coss,Melody E. Clark,Sara B. Hall,Mark P. Kamps,Pamela L. Mellon +8 more
TL;DR: Cotransfection experiments indicate that TALE proteins are essential for GnRH promoter activity in the GT1-7 cells, and Pbx1 and Oct-1, as well as Prep1 and Prep1, form functional complexes that enhance GnRH gene expression.
53
An Immortal Cell Culture Model of Hypothalamic Gonadotropin-Releasing Hormone Neurons
Pamela L. Mellon,Satish A. Eraly,Denise D. Belsham,Mark A. Lawson,Melody E. Clark,David B. Whyte,Jolene J. Windle +6 more
TL;DR: The GT1 cell lines serve as an excellent model for molecular, pharmacological, electrophysiological, and biochemical investigations into the regulation of GnRH and the characteristics of a pure CNS neuronal population.
21
Chapter 1 Molecular aspects of GnRH gene expression
Melody E. Clark,Mark A. Lawson,Denise D. Belsham,Satish A. Eraly,Pamela L. Mellon +4 more
- 01 Jan 1997
TL;DR: It is hoped that by understanding the molecular mechanisms underlying GnRH synthesis, rational treatments for endocrine and reproductive diseases involving GnRH will result.
9
The POU homeodomain transcription factor Oct-1 is essential for activity of the gonadotropin-releasing hormone neuron-specific enhancer.
Melody E. Clark,Pamela L. Mellon +1 more
TL;DR: In this paper, the authors derived cell lines from tumors created in transgenic mice by targeting simian virus 40 T antigen expression by using the regulatory regions of the gene for gonadotropin-releasing hormone (GnRH), released from specialized neurons in the hypothalamus.