Melis Karaca
University of Geneva
15 Papers
35 Citations
Melis Karaca is an academic researcher from University of Geneva. The author has contributed to research in topics: Glutamate dehydrogenase & Glutamate receptor. The author has an hindex of 13, co-authored 15 publications. Previous affiliations of Melis Karaca include Geneva College.
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Papers
Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells
TL;DR: Glucose stimulates PP secretion and PP inhibits glucagon release in mouse pancreatic islets, demonstrating glucose-regulated secretion of PP and its effects on glucagonRelease through PPYR1 receptors expressed by alpha-cells.
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Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.
Francesca Frigerio,Melis Karaca,Mathias De Roo,Vladimir Mlynarik,Dorte M. Skytt,Stefania Carobbio,Kamilla Pajęcka,Helle S. Waagepetersen,Rolf Gruetter,Dominique Muller,Pierre Maechler +10 more
TL;DR: Present data show that the lack of GDH in the CNS modifies the metabolic handling of glutamate without altering synaptic transmission, showing that GDH is required for Krebs cycle pathway.
From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis
TL;DR: Specificities of GDH regulation in neuroendocrine cells, in particular pancreatic islets and central nervous system are discussed, and its function regarding metabolic homeostasis varies greatly according to specific organs.
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Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation
Michaela C. Hohnholt,Vibe H Andersen,Jens V. Andersen,Sofie K. Christensen,Melis Karaca,Pierre Maechler,Helle S. Waagepetersen +6 more
TL;DR: Respiration fuelled by glutamate was significantly lower in brain mitochondria from GDH KO mice and synaptosomes were not able to increase their respiration upon an elevated energy demand, and it may reflect the large allosteric activation of GDH by ADP.
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Liver Glutamate Dehydrogenase Controls Whole Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis
Melis Karaca,Juliette Martin-Levilain,Mariagrazia Grimaldi,Lingzi Li,Eva Dizin,Yalin Emre,Pierre Maechler +6 more
TL;DR: The central role of hepatic GDH as a major regulator for the maintenance of ammonia and whole-body energy homeostasis is demonstrated by generating inducible liver-specific GDH-knockout mice.