Mekki F. Bensaci
Utah State University
15 Papers
247 Citations
Mekki F. Bensaci is an academic researcher from Utah State University. The author has contributed to research in topics: Aminoglycoside & Neomycin. The author has an hindex of 10, co-authored 11 publications. Previous affiliations of Mekki F. Bensaci include Southern Research Institute.
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Papers
Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin.
Bryan Elchert,Jie Li,Jinhua Wang,Yu Hui,Ravi Rai,Roger Ptak,Priscilla Ward,Jon Y. Takemoto,Mekki F. Bensaci,Cheng-Wei Tom Chang +9 more
TL;DR: Although the antibacterial activity of pyranmycins against aminoglycoside resistant bacteria is less than expected, the synthetic methodologies of utilizing a library of aminosugars can be a model for future studies of glycodiversification or glycorandomization.
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Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides.
Cheng-Wei Tom Chang,Marina Y. Fosso,Yukie Kawasaki,Sanjib K. Shrestha,Mekki F. Bensaci,Jinhua Wang,Conrad K. Evans,Jon Y. Takemoto +7 more
TL;DR: It is shown that attachment of a C8 alkyl chain to ring III of a neamine-based aminoglycoside specifically at the 4″-O position yields a broad-spectrum fungicide (FG08) without the antibacterial properties typical for aminoliccosides.
Novel Cyclic Lipodepsipeptide from Pseudomonas syringae pv. lachrymans Strain 508 and Syringopeptin Antimicrobial Activities
Ingeborg Grgurina,Mekki F. Bensaci,Gabriella Pocsfalvi,Luisa Mannina,Luisa Mannina,Oscar Cruciani,Alberto Fiore,Vincenzo Fogliano,Kevin N. Sorensen,Jon Y. Takemoto +9 more
TL;DR: Structural-activity analyses of the SP508 and SP22 homologs indicated chemical structural features that lead to enhanced antimycobacterial activity by these pseudomonad cyclic lipodepsipeptides.
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Synthesis of trehalose-based compounds and their inhibitory activities against Mycobacterium smegmatis.
Jinhua Wang,Bryan Elchert,Yu Hui,Jon Y. Takemoto,Mekki F. Bensaci,John Wennergren,Huiwen Chang,Ravi Rai,Cheng-Wei Tom Chang +8 more
TL;DR: The synthesis of a library of trehalose-based compounds has been accomplished, and their activities against Mycobacterium smegmatis have been determined, and a preliminary structure-activity relationship (SAR) is reported.
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Application of the Synthetic Aminosugars for Glycodiversification: Synthesis and Antimicrobial Studies of Pyranmycin.
Bryan Elchert,Jie Li,Jinhua Wang,Yu Hui,Ravi Rai,Roger Ptak,Priscilla Ward,Jon Y. Takemoto,Mekki F. Bensaci,Cheng-Wei Tom Chang +9 more
TL;DR: A divergent approach was employed for the synthesis of aminosugars, from which a novel library of aminoglycoside antibiotics (pyranmycins) was synthesized as mentioned in this paper.
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