Mei Zhou
Columbia University
5 Papers
6 Citations
Mei Zhou is an academic researcher from Columbia University. The author has contributed to research in topics: Gene expression profiling & Downregulation and upregulation. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Mei Zhou include University of Texas at Dallas.
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Papers
Gene expression profiling reveals the profound upregulation of hypoxia-responsive genes in primary human astrocytes.
Sarah M. Mense,Amitabha Sengupta,Mei Zhou,Changgui Lan,Galina Bentsman,David J. Volsky,Li Zhang +6 more
TL;DR: A global view of the signaling and regulatory network mediating oxygen regulation in human astrocytes is provided and many target genes of the EGF and insulin signaling pathways and the transcriptional regulators Myc, Jun, and p53 were selectively altered by hypoxia in astroCytes.
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The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes.
Sarah M. Mense,Amitabha Sengupta,Changgui Lan,Mei Zhou,Galina Bentsman,David J. Volsky,Robin M. Whyatt,Frederica P. Perera,Li Zhang +8 more
TL;DR: Results suggest that inflammatory activation of astrocytes might be an important mechanism underlying neurotoxicity of both chlorpyrifos and cyfluthrin.
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A predictive model of the oxygen and heme regulatory network in yeast.
Anshul Kundaje,Xiantong Xin,Changgui Lan,Steve Lianoglou,Steve Lianoglou,Mei Zhou,Li Zhang,Christina S. Leslie +7 more
TL;DR: A new machine learning algorithm called MEDUSA is used to uncover detailed information about the oxygen regulatory network using genome-wide expression changes in response to perturbations in the levels of oxygen, heme, Hap1, and Co2+.
Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells.
Amitabha Sengupta,Sarah M. Mense,Changgui Lan,Mei Zhou,Rory E. Mauro,Lisa Kellerman,Galina Bentsman,David J. Volsky,Elan D. Louis,Joseph H. Graziano,Li Zhang +10 more
TL;DR: Genetic analyses show that Mn(2+) selectively affects cell cycle progression, the expression of hypoxia-responsive genes, and theexpression of proinflammatory factors in primary human astrocytes, providing important insights into the molecular mechanisms underlying Mn neurotoxicity.
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human astrocytes upregulation of hypoxia-responsive genes in primary Gene expression profiling reveals the profound
Sarah M. Mense,Amitabha Sengupta,Mei Zhou,Changgui Lan,G. Bentsman,D. J. Volsky +5 more
- 01 Jan 2006
TL;DR: Human astrocytes upregulation of hypoxia-responsive genes in primary Gene expression profiling reveals the profound effects of prokaryotes to eukaryotes on physiology.
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