Mehtap Bacioglu
German Center for Neurodegenerative Diseases
5 Papers
Mehtap Bacioglu is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases.
Mehtap Bacioglu,Luis F. Maia,Oliver Preische,Juliane Schelle,Juliane Schelle,Anja Apel,Stephan A. Kaeser,Manuel Schweighauser,Manuel Schweighauser,Timo Eninger,Timo Eninger,Marius Lambert,Marius Lambert,Andrea Pilotto,Andrea Pilotto,Derya R. Shimshek,Ulf Neumann,Philipp J. Kahle,Philipp J. Kahle,Matthias Staufenbiel,Matthias Staufenbiel,Manuela Neumann,Walter Maetzler,Walter Maetzler,Jens Kuhle,Mathias Jucker,Mathias Jucker +26 more
TL;DR: It is suggested that CSF and particularly blood NfL can serve as a reliable and easily accessible biomarker to monitor disease progression and treatment response in mouse models and potentially in human proteopathic neurodegenerative diseases.
378
New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
Yang Yang,Holly J. Garringer,Yang Shi,Sofia Lövestam,Xianjun Zhang,Abhay Kotecha,Mehtap Bacioglu,Atsuo Koto,Masaki Takao,Maria Grazia Spillantini,Bernardino Ghetti,R. Vidal,Alexey G. Murzin,Sjors H.W. Scheres,Michel Goedert +14 more
TL;DR: A 21-nucleotide duplication in one allele of SNCA was identified in a previously described disease with abundant α-synuclein inclusions that was now called juvenile-onset synucleinopathy (JOS), resulting in a protein of 147 amino acids as discussed by the authors .
Signatures of glial activity can be detected in the CSF proteome
Timo Eninger,Stephan A. Müller,Mehtap Bacioglu,Manuel Schweighauser,Marius Lambert,Luis F. Maia,Jonas J. Neher,Sarah M Hornfeck,Ulrike Obermüller,Gernot Kleinberger,Christian Haass,Philipp J. Kahle,Matthias Staufenbiel,Lingyan Ping,Duc M. Duong,Allan I. Levey,Nicholas T. Seyfried,Stefan F. Lichtenthaler,Mathias Jucker,Stephan A. Kaeser +19 more
TL;DR: Proteome analysis in cerebrospinal fluid of mouse models of AD and PD pathology allowed us to identify a panel of glial CSF proteins that largely match the transcriptomic changes, supporting their relevance as biomarker candidates to stage glial activation in patients with neurodegenerative diseases.
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Post-mortem validation of in vivo TSPO PET as a microglial biomarker.
Sasvi S Wijesinghe,James B Rowe,Hannah D. Mason,Kieren Allinson,Reuben J. Thomas,Davi Vontobel,Tim D. Fryer,Young T. Hong,Mehtap Bacioglu,Maria Grazia Spillantini,Jelle van den Ameele,J. O'Brien,Sanne S Kaalund,Maura Malpetti,Annelies Quaegebeur +14 more
- 26 Feb 2025