Mehdi Almant
University of Picardie Jules Verne
4 Papers
192 Citations
Mehdi Almant is an academic researcher from University of Picardie Jules Verne. The author has contributed to research in topics: Binding site & Isothermal titration calorimetry. The author has an hindex of 4, co-authored 4 publications.
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Papers
Clustering of Escherichia coli Type‐1 Fimbrial Adhesins by Using Multimeric Heptyl α‐D‐Mannoside Probes with a Carbohydrate Core
Mehdi Almant,Vincent Moreau,José Kovensky,Julie Bouckaert,Julie Bouckaert,Sébastien G. Gouin,Sébastien G. Gouin +6 more
TL;DR: A one-pot synthetic approach was developed to tether the ligands and the fluorescein isothiocyanate probe to the scaffold simultaneously, and an FITC-labeled HM trimer showed capture and cross-linking of living bacteria in solution, a phenomenon not previously described with low-valency ligands.
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Heptyl α‐D‐Mannosides Grafted on a β‐Cyclodextrin Core To Interfere with Escherichia coli Adhesion: An In Vivo Multivalent Effect
Julie Bouckaert,Zhaoli Li,Catarina Xavier,Mehdi Almant,Vicky Caveliers,Tony Lahoutte,Stephen D. Weeks,José Kovensky,Sébastien G. Gouin,Sébastien G. Gouin +9 more
TL;DR: The heptavalent β-CDs proved to be much more effective anti-adhesive agents than monovalent references with doses of around 2 μg instilled in the mouse bladder leading to a significantly decreased E. coli load.
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A click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and biodistribution of the new radiolabelled glucose conjugates.
Eric Benoist,Yvon Coulais,Mehdi Almant,José Kovensky,Vincent Moreau,David Lesur,Marine Artigau,Claude Picard,Chantal Galaup,Sébastien G. Gouin +9 more
TL;DR: An efficient protocol was developed to tether chelating agents and rhenium complexes onto a glucoside scaffold with a heterogeneous copper catalyst via click chemistry and M(CO)(3)-glucoconjugates displayed excellent in vitro stability, a fast in vivo blood clearance and a low specific organ uptake or long-term retention in spleen and stomach.
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Probing the Nature of the Cluster Effect Observed with Synthetic Multivalent Galactosides and Peanut Agglutinin Lectin
Mehdi Almant,Amira Mastouri,Laura Gallego-Yerga,José M. García Fernández,Carmen Ortiz Mellet,José Kovensky,Sandrine Morandat,Karim El Kirat,Sébastien G. Gouin,Sébastien G. Gouin +9 more
TL;DR: Results suggest that the cluster effect that operates in ELLA with the multimers is not related to additional PNA stabilizations and can be ascribed to local concentration effects that favor a dynamic turnover of the tethered galactosides in the PNA binding sites.
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