Megumi Narita

TL;DR: This work generated induced pluripotent stem cells capable of germline transmission from murine somatic cells by transd, and demonstrated the ability of these cells to reprogram into patient-specific and disease-specific stem cells.

TL;DR: In mice, L-Myc promoted germline transmission, but not tumor formation, in the iPSC-derived chimeric mice, demonstrating that different functional moieties of the Myc proto-oncogene products are involved in the transformation and promotion of directed reprogramming.

TL;DR: It is shown that dynamic regulation of human endogenous retroviruses (HERVs) is important in the reprogramming process toward iPSCs, and in re-establishment of differentiation potential.

TL;DR: An efficient method for purifying cells based on endogenous miRNA activity and designed synthetic mRNAs encoding a fluorescent protein tagged with sequences targeted by miRNAs expressed by the cells of interest to purify cell populations for which other isolation strategies are unavailable.