Meghan E. Kapp
Vanderbilt University Medical Center
37 Papers
86 Citations
Meghan E. Kapp is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 30 publications. Previous affiliations of Meghan E. Kapp include Vanderbilt University.
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Papers
SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells
Katie C. Coate,Jeeyeon Cha,Shristi Shrestha,Wenliang Wang,Luciana Mateus Gonçalves,Joana Almaça,Meghan E. Kapp,Maria Fasolino,Ashleigh Morgan,Chunhua Dai,Diane C. Saunders,Rita Bottino,Radhika Aramandla,Regina Jenkins,Roland Stein,Klaus H. Kaestner,Golnaz Vahedi,Marcela Brissova,Alvin C. Powers,Alvin C. Powers +19 more
TL;DR: Findings reduce the likelihood that SARS-CoV-2 directly infects β cells in vivo through ACE2 and TMPRSS2 through co-expression of its canonical cell entry factors, angiotensin converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPR SS2).
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Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium.
Bryce A. Schuler,A. Christian Habermann,Erin J. Plosa,Chase J. Taylor,Christopher S. Jetter,Nicholas M. Negretti,Meghan E. Kapp,John T. Benjamin,Peter Gulleman,David S. Nichols,Lior Z. Braunstein,Alice Hackett,Michael Koval,Susan H. Guttentag,Timothy S. Blackwell,Steven A. Webber,Nicholas E. Banovich,Jonathan A. Kropski,Jennifer M.S. Sucre +18 more
TL;DR: Combining single-cell RNA sequencing of developing mouse lung with temporally-resolved immunofluorescence in mouse and human lung tissue demonstrates the cellular spectrum infected by SARS-CoV-2 in lung epithelium and suggests that developmental regulation of TMPRSS2 may underlie the relative protection of infants and children from severe respiratory illness.
Histopathological findings and clinicopathologic correlation in COVID-19: a systematic review.
Stefania Caramaschi,Meghan E. Kapp,Sara E. Miller,Rosana Eisenberg,Joyce E. Johnson,Garretson Epperly,Antonino Maiorana,Guido Silvestri,Guido Silvestri,Giovanna A. Giannico +9 more
TL;DR: In this article, a large number of autopsy studies published since May 2020 have shed light on the pathophysiology of Coronavirus disease 2019 (COVID-19), and a review summarizes the histopathologic findings and clinicopathologic correlations from autopsies and biopsies performed in patients with CoV-19.
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A Multidisciplinary Housestaff-Led Initiative to Safely Reduce Daily Laboratory Testing.
Wade T. Iams,Josh M. Heck,Meghan E. Kapp,David L Leverenz,Michael A. Vella,Eszter Szentirmai,Irene Valerio-Navarrete,Cecelia Theobald,Kathryn Goggins,Kevin Flemmons,Kelly C. Sponsler,Cody H. Penrod,Patricia Kleinholz,Donald W. Brady,Sunil Kripalani +14 more
TL;DR: A housestaff-led intervention utilizing education and data feedback with goal setting and peer comparison resulted in safe, significant reductions in daily laboratory testing rates.
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
Jeffrey M. Verboon,Jeffrey M. Verboon,Dilnar Mahmut,Dilnar Mahmut,Ah Ram Kim,Ah Ram Kim,Mitsutoshi Nakamura,Nour J. Abdulhay,Nour J. Abdulhay,Satish K. Nandakumar,Satish K. Nandakumar,Namrata Gupta,Thomas E. Akie,Amy E. Geddis,Becky Manes,Meghan E. Kapp,Inga Hofmann,Inga Hofmann,Stacey Gabriel,Daryl E. Klein,David A. Williams,Haydar Frangoul,Susan M. Parkhurst,Genevieve M. Crane,Alan B. Cantor,Vijay G. Sankaran,Vijay G. Sankaran +26 more
TL;DR: It is suggested that deregulation of CDC42 may underlie more common blood disorders, such as primary myelofibrosis, and further investigation of this and other related disorders may provide insights into how hematopoietic cell-microenvironment interactions play a role in human health and can be disrupted in disease.
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