As the most common human cancer worldwide and continuing to increase in incidence, basal cell carcinoma is associated with significant morbidity and cost. Continued advances in research have refined both our insight and approach to this seemingly ubiquitous disease. This 2-part continuing medical education article will provide a comprehensive and contemporary review of basal cell carcinoma. The first article in this series describes our current understanding of this disease regarding epidemiology, cost, clinical and histopathologic presentations, carcinogenesis, natural history, and disease associations.

Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations.

"Maskne" is a new term coined during the 2020 COVID-19 pandemic. It refers to a subset of acne mechanica, deserving consideration in view of widespread reusable fabric mask-wearing to control the pandemic worldwide. Understanding of underlying pathophysiology directly relates to the novel skin microenvironment and textile-skin friction created by mask-wearing, distinct from nontextile-related acne mechanica previously linked to wearing of headgear. Specifically, the occlusive microenvironment leads to microbiome dysbiosis, which is linked to various dermatological conditions. Additional textile-skin interactions include factors such as breathability, stickiness sensations, moisture saturation, and hygiene maintenance. Increased skin temperatures can trigger sweat/heat-related dermatoses, and ear loops potentially trigger pressure-induced dermatoses. Important therapeutic considerations include increased skin irritation potential of conventional acne treatments under occlusion, exacerbation of chronic dermatoses, that is, perioral dermatitis, rosacea, and eczema, and susceptibility of these same patient groups to heightened discomfort with mask-wearing. Cotton, as the traditional fabric of choice for dermatology patients, has limited benefits in the context of face masks - increased subjective discomfort relates to increased moisture saturation and stickiness, inevitable because of high biofluid load of the nasal and oral orifices. Prolonged textile-skin contact time, directly proportional to the risk of maskne, can be an opportunity for the application of biofunctional textiles.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ijd.15425

The "Maskne" microbiome - pathophysiology and therapeutics.

Interest in and research on hidradenitis suppurativa (HS) have increased during the past decade, resulting in expanded knowledge about associated comorbidities and treatment efficacy Knowledge about pediatric-onset HS is still limited, based on case studies, small case series, and extrapolation from adult studies With increasing prevalence of childhood obesity, decreasing pubertal age, and increasing awareness of HS, physicians may start encountering younger HS patients This review presents an updated discussion on the epidemiology, pathophysiology, and associated comorbidities in HS, with a focus on pediatric and adolescent patients It also suggests recommendations for investigation and treatment based on current evidence

Hidradenitis suppurativa in pediatric patients.

Skincare Finishes to Textiles

Introduction Renal transplantation is an effective treatment for the end stage renal disease (ESRD). However, how salivary microbiota changes during perioperative period of renal transplant recipients (RTRs) has not been elucidated. Methods Five healthy controls and 11 RTRs who had good recovery were enrolled. Saliva samples were collected before surgery and at 1, 3, 7, and 14 days after surgery. 16S rRNA gene sequencing was performed. Results There was no significant difference in the composition of salivary microbiota between ESRD patients and healthy controls. The salivary microbiota of RTRs showed higher operational taxonomic units (OTUs) amount and greater alpha and beta diversity than those of ESRD patients and healthy controls, but gradually stabilized over time. At the phylum level, the relative abundance of Actinobacteria, Tenericutes and Spirochaetes was about ten times different from ESRD patients or healthy controls for RTRs overall in time. The relative abundance of Bacteroidetes, Fusobacteria, Patescibacteria, Leptotrichiaceae and Streptococcaceae was correlated with serum creatinine (Scr) after renal transplantation. Discussion In short, salivary microbiota community altered in the perioperative period of renal transplantation and certain species of salivary microbiota had the potential to be a biomarker of postoperative recovery.

Association between salivary microbiota and renal function in renal transplant patients during the perioperative period

Oral mucoceles are lesions arising mainly from the minor salivary glands and are thought to occur after excretory duct trauma. We report a case of multiple superficial oral mucoceles on a child's labial mucosa after Mycoplasma pneumoniae mucositis. Mucoceles can mimic persistent or recurrent stomatitis and lead to potential errors in management.

Multiple superficial oral mucoceles after Mycoplasma-induced mucositis.

Basal cell carcinoma metastases are rare. We report a case of an 83 year-old male with recurrent cutaneous infiltrative basal cell carcinoma on the right vertex with tumor aggregates of infiltrativ...

https://journals.sagepub.com/doi/pdf/10.1177/2050313X20919602

Basal cell carcinoma stroma as a mimicker of lymphatic invasion: A case report:

Mycobacterium chelonae is a species of mycobacteria that can be found ubiquitously in the environment. It can be found in soil, water, and in aquatic animals. Infections with this pathogen usually ...

https://journals.sagepub.com/doi/pdf/10.1177/2050313X19845231

Recurrence of cutaneous Mycobacterium chelonae infection: A case report.

The bilobed flap is most often used for the reconstruction of small cutaneous defect of the nose. Under certain circumstances, it can also be useful in the reconstruction of much larger defects of the face. Our objective is to report a case of bilobed flap reconstruction in a patient with a large defect of the zygomatic cheek following a Mohs micrographic surgery for lentigo maligna.

https://journals.sagepub.com/doi/pdf/10.1177/2050313X19843770

Unusual use of a common skin flap for a large cutaneous defect following Mohs surgery for lentigo maligna of the cheek: A case report:

A 58-year-old woman receiving gemcitabine and docetaxel for uterine cancer presented with hyperpigmented plaques on the dorsa of the hands and on the arms. A cutaneous side effect of chemotherapy was suspected. 

Serpentine Supravenous Hyperpigmentation.

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