Megan Stiles
University of Oklahoma Health Sciences Center
14 Papers
1 Citations
Megan Stiles is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Retinal & Sphingolipid. The author has an hindex of 5, co-authored 9 publications. Previous affiliations of Megan Stiles include University of Oklahoma.
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Papers
Distribution of ELOVL4 in the Developing and Adult Mouse Brain.
David M. Sherry,Blake R. Hopiavuori,Megan Stiles,Negar S. Rahman,Kathryn G. Ozan,Ferenc Deak,Martin-Paul Agbaga,Robert E. Anderson +7 more
TL;DR: ELOVL4 was widely expressed in the developing brain by embryonic day 18 and was especially pronounced in regions underlying the lateral ventricles and other neurogenic regions, and was primarily expressed by neurons, although presumptive oligodendrocytes located in white matter tracts also showed labeling.
Overexpression of acid ceramidase (ASAH1) protects retinal cells (ARPE19) from oxidative stress
Eriko Sugano,Genea Edwards,Saikat Saha,Lynda A. Wilmott,Richard C. Grambergs,Koushik Mondal,Hui Qi,Megan Stiles,Hiroshi Tomita,Nawajes A Mandal,Nawajes A Mandal +10 more
TL;DR: It is demonstrated that oxidative stress generates sphingolipid death mediators in retinal cells and that induction of ASAH1 could rescue Retinal cells from oxidative stress by hydrolyzing excess Cers.
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•Journal Article
Analysis of Sphingolipid Composition of Human Vitreous from Control and Diabetic Individuals
TL;DR: The results indicate changes in sphingolipid composition in the vitreous due to type 2 diabetes, which could be connected to the disease pathologies of the retina, retinal vessels, Vitreous and the surrounding tissues.
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Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, d-Serine Availability, and Astrogliosis
Matthew P Baier,Raghavendra Y. Nagaraja,Hannah P. Yarbrough,Daniel Owen,Anthony M. Masingale,Rojina Ranjit,Megan Stiles,Ashley Murphy,Martin-Paul Agbaga,Mohiuddin Ahmad,David M. Sherry,Michael Kinter,Holly Van Remmen,Sreemathi Logan +13 more
TL;DR: Astrocytic ablation of SOD2 impairs hippocampal-dependent plasticity in spatial working memory, reduces long-term potentiation of hippocampal neurons and levels of the neuromodulator d-serine, and increases astrogliosis, consistent with defects in advanced aging and Alzheimer's disease.
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Sphingosine Kinase 2 Phosphorylation of FTY720 is Unnecessary for Prevention of Light-Induced Retinal Damage
Hui Qi,Jerome Cole,Richard C. Grambergs,John R. Gillenwater,Koushik Mondal,Sufiya Khanam,Soma Dutta,Megan Stiles,Richard L. Proia,Jeremy C. Allegood,Nawajes A Mandal,Nawajes A Mandal +11 more
TL;DR: FTY720 treatment protected Sphk 2 KO retinas from light-induced damage despite significant retardation of FTY720 phosphorylation in Sphk2 KO mice, concluding that FTY 720 serves an active role in preventing photoreceptor cell death.