Megan Justice
University of North Carolina at Chapel Hill
7 Papers
22 Citations
Megan Justice is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Cohesin & Enhancer. The author has an hindex of 5, co-authored 5 publications.
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Papers
lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA.
Megan D. Schertzer,Keean C.A. Braceros,Joshua Starmer,Rachel E Cherney,David M Lee,Gabriela Salazar,Megan Justice,Steven R. Bischoff,Dale O. Cowley,Pablo Ariel,Mark J. Zylka,Jill M. Dowen,Terry Magnuson,J. Mauro Calabrese +13 more
TL;DR: It is proposed that CGIs that autonomously recruit PRCs interact with lncRNAs and their associated proteins through three-dimensional space to nucleate the spread of PRCs in lncRNA-targeted domains.
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A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression.
TL;DR: A recurrent missense mutation to the hinge domain of the cohesin subunit SMC1A, observed in acute myeloid leukemia, is investigated and a requirement for the Cohesin hinge domain in three-dimensional chromatin structure is identified.
Cohesin stabilization at promoters and enhancers by common transcription factors and chromatin regulators
Audra F Bryan,Megan Justice,Alexis V Stutzman,Daniel J. McKay,Jill M. Dowen +4 more
TL;DR: Cohesin is stabilized at promoters and enhancers by common transcription factors (SP1, NFYA) and chromatin regulators (WDR5), which physically interact and colocalize with cohesin on chromatin, regulating enhancer-promoter loops in mouse embryonic stem cells.
Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells
Nicole L Arruda,Zachary M. Carico,Megan Justice,Ying Frances Liu,Junjie Zhou,Holden C. Stefan,Jill M. Dowen +6 more
TL;DR: STAG1 and STAG2 have independent roles in cohesin localization and both overlapping and distinct roles in gene expression and these results advance the understanding of the link between mammalian genome organization and gene expression during development and disease contexts.