Megan E. Murphy
University of Wisconsin-Madison
9 Papers
2 Citations
Megan E. Murphy is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Zika virus & Biology. The author has an hindex of 4, co-authored 8 publications.
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Papers
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson’s Disease in Common Marmosets
Scott C. Vermilyea,Alexander Babinski,Nina Tran,Samantha To,Scott Guthrie,Jillian H. Kluss,Jenna Kropp Schmidt,Gregory J. Wiepz,Michael G. Meyer,Megan E. Murphy,Mark R. Cookson,Marina E. Emborg,Thaddeus G. Golos +12 more
TL;DR: The successful use of CRISPR/Cas9 with repair template-mediated homology directed repair to introduce the L RRK2 G2019S mutation, as well as a truncation of the LRRK2 kinase domain, into marmoset embryonic and induced pluripotent stem cells is reported.
Examining intersectionality and inclusivity in geosciences education research: A synthesis of the literature 2008–2018
TL;DR: This article reviewed geoscience education research published since the December 2007 “Broadening Participation” issue of the Journal of Geoscience Education to examine how research in the field has been conducted.
Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.
Chelsea M. Crooks,Andrea M. Weiler,Sierra Rybarczyk,Mason Bliss,Anna S. Jaeger,Megan E. Murphy,Heather A. Simmons,Andres Mejia,Michael K. Fritsch,Jennifer M. Hayes,Jens C. Eickhoff,Ann Mitzey,Elaina Razo,Katarina M. Braun,Elizabeth A. Brown,Keisuke Yamamoto,Phoenix M. Shepherd,Amber Possell,Kara Weaver,Kathleen M. Antony,Terry K. Morgan,Christina M. Newman,Dawn M. Dudley,Nancy Schultz-Darken,Eric Peterson,Leah C. Katzelnick,Angel Balmaseda,Eva Harris,David H. O’Connor,Emma L. Mohr,Thaddeus G. Golos,Thomas C. Friedrich,Matthew T. Aliota +32 more
TL;DR: In this paper, the authors examined the impact of pre-existing immunity to dengue virus (DENV) on ZIKV pathogenesis during pregnancy in a translational non-human primate model.
Prior dengue immunity enhances Zika virus infection of the maternal-fetal interface in rhesus macaques
Chelsea M. Crooks,Andrea M. Weiler,Sierra Rybarczyk,Mason Bliss,Anna S. Jaeger,Megan E. Murphy,Heather A. Simmons,Andres Mejia,Michael K. Fritsch,Jennifer M. Hayes,Jens C. Eickhoff,Ann Mitzey,Elaina Razo,Katarina M. Braun,Elizabeth A. Brown,Keisuke Yamamoto,Phoenix M. Shepherd,Amber Possell,Kara Weaver,Kathleen M. Antony,Terry K. Morgan,Christina M. Newman,Dawn M. Dudley,Nancy Schultz-Darken,Eric J. Peterson,Leah C. Katzelnick,Angel Balmaseda,Eva Harris,David H. O’Connor,Emma L. Mohr,Thaddeus G. Golos,Thomas C. Friedrich,Matthew T. Aliota +32 more
TL;DR: In this article, the authors examined the impact of pre-existing immunity to dengue virus (DENV) on ZIKV pathogenesis during pregnancy in a translational non-human primate model.
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African-lineage Zika virus replication dynamics and maternal-fetal interface infection in pregnant rhesus macaques.
Chelsea M. Crooks,Andrea M. Weiler,Sierra Rybarczyk,Mason Bliss,Anna S. Jaeger,Megan E. Murphy,Heather A. Simmons,Andres Mejia,Michael K. Fritsch,Jennifer M. Hayes,Jens C. Eickhoff,Ann Mitzey,Elaina Razo,Katarina M. Braun,Elizabeth A. Brown,Keisuke Yamamoto,Phoenix M. Shepherd,Amber Possell,Kara Weaver,Kathleen M. Antony,Terry K. Morgan,Xiankun Zeng,Dawn M. Dudley,Eric Peterson,Nancy Schultz-Darken,David H. O’Connor,Emma L. Mohr,Thaddeus G. Golos,Matthew T. Aliota,Thomas C. Friedrich +29 more
TL;DR: In this article, the authors provided the first comprehensive assessment of African-lineage ZIKV infection during pregnancy in a translational nonhuman primate model, and showed that the African lineage isolates replicate with kinetics similar to those of Asian lineages and can infect the placenta.